Impact of the lactate dehydrogenase in association with the International Staging System prognostic score in multiple myeloma patients treated in real life

乳酸脱氢酶与国际分期系统预后评分对现实生活中接受治疗的多发性骨髓瘤患者的影响

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作者:Maricy Almeida Viol Ferreira Lopes, Fabiana Higashi, Edvan de Queiroz Crusoe, Ana Lucia Miguel Peres, Priscilla Cury, Vania Tietsche de Moraes Hungria

Conclusion

Through the association of ISS I and normal DHL, ISS III and high DHL and others combinations, we build a new score with superior impact prognostic in our population treated in real life.

Methods

It is a retrospective cohort with 252 patients with MM recently-diagnosed that attendance in the institution of the study.

Results

To evaluate the association between DHL and ISS, we found 6 new groups to be analyzed: ISS I and normal DHL with medium overall survival not reached, and with DHL loud with medium OS of 69,8 months, ISS II and normal DHL with medium overall survival of 78,8 months and with DHL loud with medium OS of 73,9 months, ISS III and normal DHL with medium overall survival of 46,7 months and with DHL loud with medium OS of 45,5 months.

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