Humanized Patient-derived Xenograft Models of Disseminated Ovarian Cancer Recapitulate Key Aspects of the Tumor Immune Environment within the Peritoneal Cavity

播散性卵巢癌人源化患者异种移植模型重现腹腔内肿瘤免疫环境的关键方面

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作者:Mara P Steinkamp, Irina Lagutina, Kathryn J Brayer, Fred Schultz, Danielle Burke, Vernon S Pankratz, Sarah F Adams, Laurie G Hudson, Scott A Ness, Angela Wandinger-Ness

Significance

huPDX models are ideal preclinical models for testing novel therapies. They reflect the genetic heterogeneity of the patient population, enhance human myeloid differentiation, and recruit immune cells to the tumor microenvironment.

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