CD47-blocking Antibody ZL-1201 Promotes Tumor-associated Macrophage Phagocytic Activity and Enhances the Efficacy of the Therapeutic Antibodies and Chemotherapy

CD47阻断抗体ZL-1201促进肿瘤相关巨噬细胞吞噬活性并增强治疗抗体和化疗的疗效

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作者:Anthony Cao, Jiaqing Yi, Xinyan Tang, Christopher W Szeto, Renyi Wu, Bing Wan, Xu Fang, Shou Li, Lei Wang, Lina Wang, Jing Li, Qiuping Ye, Tom Huang, Karl Hsu, Omar Kabbarah, Haiying Zhou

Significance

ZL-1201 is a novel anti-CD47 antibody that has improved hematologic safety profiles and combines with SoC, including mAbs and chemotherapies, to potently facilitate phagocytosis and antitumor efficacy.

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