Synthesis of Some Benzimidazole Derivatives Bearing 1,3,4-Oxadiazole Moiety as Anticancer Agents
含1,3,4-恶二唑基团的苯并咪唑衍生物的合成及其作为抗癌剂的应用
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作者：Bereket Mochona, Elizabeth Mazzio, Madhavei Gangapurum, Nelly Mateeva, K K Redda
| 期刊： | Chem Sci Trans | 影响因子： | |
| 时间： | 2015 | 起止号： | 2015 Apr;4(2):534-540. |
| doi： | 10.7598/cst2015.1029 | 研究方向： | 肿瘤 |
Abstract
In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (5a-i) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (5c) exhibited moderate cytotoxicity.
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