Brain activity and upper limb movement analysis in children with Down syndrome undergoing transcranial direct current stimulation combined with virtual reality training: study protocol for a randomized controlled trial

接受经颅直流电刺激结合虚拟现实训练的唐氏综合症儿童的大脑活动和上肢运动分析:一项随机对照试验的研究方案

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作者:Jamile Benite Palma Lopes, Isabela Marques Miziara, Danial Kahani, Rodolfo Borges Parreira, Natalia de Almeida Carvalho Duarte, Roberta Delasta Lazzari, Lucas Villalta Santos, Carlos Bandeira de Mello Monteiro, Deborah Carvalho da Silva Cardoso, Juliana de Oliveira Hassel Mendes, Vera Lucia Dos Sant

Background

Children with Down syndrome have poorer functional and sensory skills compared to children with typical development. Virtual reality (VR) training could help improve these skills. Moreover, transcranial direct current stimulation (tDCS) has achieved promising

Discussion

The optimization of the results obtained with virtual reality training is believed to be related to the interactive experience with a wide range of activities and scenarios involving multiple sensory channels and the creation of exercises, the intensity of which can be adjusted to the needs of children. Therefore, the proposed study aims to complement the literature with further information on tDCS and VR training considering different variables to provide the scientific community with clinical data on this combination of interventions.

Trial registration

Brazilian Clinical Trials Registry (REBEC) protocol number RBR-43pk59 registered on 2019 March 27 https://ensaiosclinicos.gov.br/rg/RBR-43pk59 and Human Research Ethics Committee number 3.608.521 approved on 2019 September 30. Protocol version 2021 October 20. Any changes to the protocol will be reported to the committees and approved. Informed consent will be obtained from all participants by the clinical research coordinator and principal investigator.

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