Effects of physical training on functional, clinical, morphological, behavioural and psychosocial outcomes in post-COVID-19 infection: COVID-19 and REhabilitation study (CORE-study)-a study protocol for a randomised controlled clinical trial

体能训练对新冠肺炎感染后功能、临床、形态、行为和社会心理结果的影响:新冠肺炎和康复研究(CORE 研究)——一项随机对照临床试验的研究方案

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作者:Rodrigo Sudatti Delevatti, Angelica Danielevicz, Maria Eduarda Sirydakis, Paulo Urubatan Gama de Melo, Cíntia de la Rocha Freitas, Cassiano Ricardo Rech, Luiz Guilherme Antonacci Guglielmo, Guilherme Fleury Fina Speretta, Fernanda Hansen, Fernanda Rodrigues Fonseca, Ana Carolina Starke, Ricardo Dant

Background

The COVID-19 pandemic remains ongoing, with a significant number of survivors who have experienced moderate to severe clinical conditions and who have suffered losses of great magnitude, especially in functional capacity, triggering limitations to daily autonomy and quality of life. Among the possibilities of intervention for disease rehabilitation, physical exercise training stands out, which can benefit several health outcomes and favours the adoption of healthier behaviours. Therefore, the

Discussion

This study will contribute to a greater understanding of the safety, adherence and benefits of physical training in the rehabilitation of post-COVID-19 patients. The results of this study will be disseminated through presentations at congresses, workshops, peer-reviewed publications and local and international conferences, especially with a view to proposing a post-COVID-19 rehabilitation care protocol.

Methods

A randomised controlled clinical trial is to be conducted in parallel, with the experimental group undergoing an intervention involving a multicomponent physical rehabilitation programme, carried out at the Sports Center in partnership with the Academic Hospital of the Federal University of Santa Catarina, in Florianópolis, Brazil. Participants will be adults and the elderly, of both sexes, in a post-COVID-19-infection state, who were hospitalised during the infection. The intervention will have a total duration of 24 weeks and will include a multicomponent physical training programme, which will have gradual progression in frequency, duration and intensity over time. Regarding the outcomes, before, at the 12th and after 24 weeks of intervention, functional (primary outcome = functional index of aerobic capacity), clinical, morphological, behavioural and psychosocial outcomes will be assessed.

Trial registration

ReBEC, RBR-10y6jhrs . Registered on 22 February 2022. 2015.

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