Neuroforensomics: metabolites as valuable biomarkers in cerebrospinal fluid of lethal traumatic brain injuries

神经法医学:代谢物作为致命创伤性脑损伤脑脊液中的宝贵生物标志物

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作者:Simone Bohnert #, Christoph Reinert #, Stefanie Trella, Andrea Cattaneo, Ulrich Preiß, Michael Bohnert, Johann Zwirner, Andreas Büttner, Werner Schmitz, Benjamin Ondruschka

Results

numerous metabolites were identified that showed significant concentration differences in the post mortem CSF for lethal acute TBI (survival times up to 90 min) compared to CVF. For the first time, this forensic study provides an evaluation of a new generation of biomarkers for diagnosing TBI in the differentiation to other causes of death, here CVF, as surrogate markers for the post mortem assessment of complex neuropathological processes in the CNS ("neuroforensomics").

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