Background
Low effectiveness of chemotherapy in ovarian cancer
Conclusion
Our results suggest that upregulation of MYOT can be related to TOP resistance in ovarian cancer cell lines.
Methods
We analyzed development of TOP resistance in ovarian cancer cell lines (A2780 and W1). On the base of our previous
Results
We observed increased expression of MYOT in TOP resistant cell lines at both mRNA and protein level. MYOT, together with extracellular matrix molecules like COL1A2 and COL15A1 were also secreted to corresponding cell culture media.