In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci
Aurein 1.2 单独和与抗生素联合对院内革兰氏阳性球菌的体外活性
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作者：Andrea Giacometti, Oscar Cirioni, Alessandra Riva, Wojciech Kamysz, Carmela Silvestri, Piotr Nadolski, Agnese Della Vittoria, Jerzy Łukasiak, Giorgio Scalise
Abstract
This study was performed to evaluate the in vitro activity of the amphibian peptide aurein 1.2 and to investigate its interaction with six antibiotics against nosocomial gram-positive cocci. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when aurein 1.2 was combined with clarithromycin and minocycline.
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