In vitro activities of voriconazole, itraconazole, and terbinafine alone or in combination against Pythium insidiosum isolates from Brazil
伏立康唑、伊曲康唑和特比萘芬单独或联合使用对巴西腐霉分离株的体外活性
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作者：Juliana S Argenta, Janio M Santurio, Sydney H Alves, Daniela I B Pereira, Ayrton S Cavalheiro, Andréia Spanamberg, Laerte Ferreiro
Abstract
We evaluated the in vitro activities of voriconazole, itraconazole, and terbinafine against 30 clinical isolates of Pythium insidiosum using a checkerboard macrodilution method. The combined activity of terbinafine plus itraconazole or plus voriconazole was synergic against 17% of the strains. Antagonism was not observed.
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