Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report

脐带间充质基质细胞输注治疗出现肺纤维化的新冠肺炎危重患者后的免疫调节和抗纤维化作用:病例报告

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作者:Kátia Nunes da Silva, Priscila Carvalho Guedes Pinheiro, André Luiz Nunes Gobatto, Rogério da Hora Passos, Bruno Diaz Paredes, Luciana Souza de Aragão França, Carolina Kymie Vasques Nonaka, Beatriz Barreto-Duarte, Mariana Araújo-Pereira, Rafael Tibúrcio, Fernanda Ferreira Cruz, Gabriele Louise Soare

Background

The patients with coronavirus disease 2019 (COVID-19) associated with severe acute respiratory distress syndrome (ARDS) may require prolonged mechanical ventilation which often

Conclusions

Mesenchymal stromal cell therapy may be a promising option in critically ill patients with COVID-19 presenting both severe lung inflammation and fibrosis. Further clinical trials could better assess the efficacy of MSC therapy in critically ill patients with COVID-19 with lung fibrosis associated with long-term mechanical ventilation.

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