Abstract
Given their versatile nature and wide range of possible applications, core-shell nanoparticles (NPs) have received considerable attention. This paper proposes a novel method for synthesizing ZnO@NiO core-shell nanoparticles using a hybrid technique. The characterization demonstrates the successful formation of ZnO@NiO core-shell nanoparticles, which have an average crystal size of 13.059 nm. The results indicate that the prepared NPs have excellent antibacterial activity against both Gram-negative and Gram-positive bacteria. This behavior is primarily caused by the accumulation of ZnO@NiO NPs on the bacteria's surface, which results in cytotoxic bacteria and a relatively increased ZnO, resulting in cell death. Moreover, the use of a ZnO@NiO core-shell material will prevent the bacteria from nourishing themselves in the culture medium, among many other reasons. Finally, the PLAL is an easily scalable, cost-effective, and environmentally friendly method for the synthesis of NPs, and the prepared core-shell NPs could be used in other biological applications such as drug delivery, cancer treatment, and further biomedical functionalization.