日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small-molecule inhibitors of Slack potassium channels as potential therapeutics for childhood epilepsies

小分子Slack钾通道抑制剂作为治疗儿童癫痫的潜在药物

M Qunies, Alshaima'a; A Emmitte, Kyle

Stress and interferon signalling-mediated apoptosis contributes to pleiotropic anticancer responses induced by targeting NGLY1

应激和干扰素信号介导的细胞凋亡有助于靶向 NGLY1 诱导的多效抗癌反应

Ashwini Zolekar, Victor J T Lin, Nigam M Mishra, Yin Ying Ho, Hamed S Hayatshahi, Abhishek Parab, Rohit Sampat, Xiaoyan Liao, Peter Hoffmann, Jin Liu, Kyle A Emmitte, Yu-Chieh Wang

Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core

基于截短的吡啶酰胺核心的具有改进效力和中枢神经系统渗透性的 mGlu2 NAM 的设计和合成

Katrina A Bollinger, Andrew S Felts, Christopher J Brassard, Julie L Engers, Alice L Rodriguez, Rebecca L Weiner, Hyekyung P Cho, Sichen Chang, Michael Bubser, Carrie K Jones, Anna L Blobaum, Colleen M Niswender, P Jeffrey Conn, Kyle A Emmitte, Craig W Lindsley

Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors

使用 RAD52 小分子抑制剂靶向 BRCA1 和 BRCA2 缺陷细胞

Fei Huang, Nadish Goyal, Katherine Sullivan, Kritika Hanamshet, Mikir Patel, Olga M Mazina, Charles X Wang, W Frank An, James Spoonamore, Shailesh Metkar, Kyle A Emmitte, Simon Cocklin, Tomasz Skorski, Alexander V Mazin

Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity

评估 P450 活性减弱的大鼠体内混合醛氧化酶/细胞色素 P450 底物的分布

Rachel D Crouch, Ryan D Morrison, Frank W Byers, Craig W Lindsley, Kyle A Emmitte, J Scott Daniels

VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy

VU0477573:具有体内功效的亚型 5 代谢型谷氨酸受体的部分负变构调节剂

Hilary Highfield Nickols, Joannes P Yuh, Karen J Gregory, Ryan D Morrison, Brittney S Bates, Shaun R Stauffer, Kyle A Emmitte, Michael Bubser, Weimin Peng, Michael T Nedelcovych, Analisa Thompson, Xiaohui Lv, Zixiu Xiang, J Scott Daniels, Colleen M Niswender, Craig W Lindsley, Carrie K Jones, P Jeff

Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles

具有不同体外结合特性的代谢型谷氨酸受体 5 亚型变构调节剂的体内受体占有率与疗效之间的关系

Jerri M Rook, Mohammed N Tantawy, Mohammad S Ansari, Andrew S Felts, Shaun R Stauffer, Kyle A Emmitte, Robert M Kessler, Colleen M Niswender, J Scott Daniels, Carrie K Jones, Craig W Lindsley, P Jeffrey Conn

Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM)

发现 (R)-(2-氟-4-((-4-甲氧基苯基)乙炔基)苯基) (3-羟基哌啶-1-基)甲酮 (ML337),一种 mGlu3 选择性和 CNS 渗透性负变构调节剂 (NAM)

Cody J Wenthur, Ryan Morrison, Andrew S Felts, Katrina A Smith, Julie L Engers, Frank W Byers, J Scott Daniels, Kyle A Emmitte, P Jeffrey Conn, Craig W Lindsley

N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats

N-酰基-N'-芳基哌嗪作为 mGlu1 的负变构调节剂:鉴定 VU0469650,一种在大鼠中枢神经系统中具有暴露作用的强效选择性工具化合物

Kimberly M Lovell, Andrew S Felts, Alice L Rodriguez, Daryl F Venable, Hyekyung P Cho, Ryan D Morrison, Frank W Byers, J Scott Daniels, Colleen M Niswender, P Jeffrey Conn, Craig W Lindsley, Kyle A Emmitte

(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction

mGlu(5) 的 (3-氰基-5-氟苯基)联芳负变构调节剂:发现一种在 OSS 小鼠成瘾模型中具有活性的新型工具化合物

Craig W Lindsley, Brittney S Bates, Usha N Menon, Satyawan B Jadhav, Alexander S Kane, Carrie K Jones, Alice L Rodriguez, P Jeffrey Conn, Christopher M Olsen, Danny G Winder, Kyle A Emmitte