日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Quinoline-Based Neuropilin‑1 Antagonists Exhibit a Pure Antagonist Profile and Block Vascular Endothelial Growth Factor-Induced Pain

基于喹啉的神经纤毛蛋白-1拮抗剂表现出纯拮抗剂特性,并能阻断血管内皮生长因子诱导的疼痛。

Hestehave, Sara; Dragoni, Silvia; Fallon, Philip; Mota, Filipa; Calderon-Rivera, Aida; Gomez, Kimberly; Powell, Jonathan; Patsiarika, Anastasia; Reisinger, Tifelle; Crosby, Stuart; Chan, A W Edith; Steadman, David; Winfield, Natalie; Jarvis, Ashley; Martin, John; Zachary, Ian C; Frankel, Paul; Djordjevic, Snezana; Ruhrberg, Christiana; Khanna, Rajesh; Selwood, David L

Deciphering the Coevolutionary Dynamics of L2 β-Lactamases via Deep Learning

利用深度学习解析L2 β-内酰胺酶的协同进化动力学

Zhu, Yu; Gu, Jing; Zhao, Zhuoran; Chan, A W Edith; Mojica, Maria F; Hujer, Andrea M; Bonomo, Robert A; Haider, Shozeb

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

一种用于心脏保护和神经再生的PI3Kα小分子激活剂

Grace Q Gong ,Benoit Bilanges ,Ben Allsop ,Glenn R Masson ,Victoria Roberton ,Trevor Askwith ,Sally Oxenford ,Ralitsa R Madsen ,Sarah E Conduit ,Dom Bellini ,Martina Fitzek ,Matt Collier ,Osman Najam ,Zhenhe He ,Ben Wahab ,Stephen H McLaughlin ,A W Edith Chan ,Isabella Feierberg ,Andrew Madin ,Daniele Morelli ,Amandeep Bhamra ,Vanesa Vinciauskaite ,Karen E Anderson ,Silvia Surinova ,Nikos Pinotsis ,Elena Lopez-Guadamillas ,Matthew Wilcox ,Alice Hooper ,Chandni Patel ,Maria A Whitehead ,Tom D Bunney ,Len R Stephens ,Phillip T Hawkins ,Matilda Katan ,Derek M Yellon ,Sean M Davidson ,David M Smith ,James B Phillips ,Richard Angell ,Roger L Williams ,Bart Vanhaesebroeck

Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice

类大麻素化合物VSN16R逆转脆性X综合征小鼠的行为表型

Hurley, Michael J; Deacon, Robert M J; Chan, A W Edith; Baker, David; Selwood, David L; Cogram, Patricia

Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease

利用从头设计的抑制剂在视网膜疾病模型中验证GEF-H1的治疗效果

Clare Mills ,Sandra A Hemkemeyer ,Zerin Alimajstorovic ,Chantelle Bowers ,Malihe Eskandarpour ,John Greenwood ,Virginia Calder ,A W Edith Chan ,Paul J Gane ,David L Selwood ,Karl Matter ,Maria S Balda

Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1

血管内皮生长因子 B 衍生的肽与神经纤毛蛋白-1 有强效结合

Filipa Mota, Tamas Yelland, Jennie A Hutton, Jennifer Parker, Anastasia Patsiarika, A W Edith Chan, Andrew O'Leary, Constantina Fotinou, John F Martin, Ian C Zachary, Snezana Djordjevic, Paul Frankel, David L Selwood

In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors

在晶体筛选中发现人类诺如病毒3C样蛋白酶抑制剂

Guo, Jingxu; Douangamath, Alice; Song, Weixiao; Coker, Alun R; Chan, A W Edith; Wood, Steve P; Cooper, Jonathan B; Resnick, Efrat; London, Nir; Delft, Frank von

N(10) -carbonyl-substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress

N(10)-羰基取代的吩噻嗪类化合物能够抑制脂质过氧化及其相关的氧化氮消耗,从而有效保护脑组织免受氧化应激的损害。

Keynes, Robert G; Karchevskaya, Anastasia; Riddall, Dieter; Griffiths, Charmaine H; Bellamy, Tomas C; Chan, A W Edith; Selwood, David L; Garthwaite, John

Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells

小分子神经纤毛蛋白-1拮抗剂通过减少调节性T细胞中转化生长因子β(TGFβ)的产生,将抗血管生成和抗肿瘤活性与免疫调节相结合。

Jonathan Powell ,Filipa Mota ,David Steadman ,Christelle Soudy ,Jeremy T Miyauchi ,Stuart Crosby ,Ashley Jarvis ,Tifelle Reisinger ,Natalie Winfield ,Graham Evans ,Aled Finniear ,Tamas Yelland, Yi-Tai Chou ,A W Edith Chan ,Andrew O'Leary ,Lili Cheng ,Dan Liu ,Constantina Fotinou ,Carla Milagre ,John F Martin ,Haiyan Jia ,Paul Frankel ,Snezana Djordjevic ,Stella E Tsirka ,Ian C Zachary ,David L Selwood

Architecture and hydration of the arginine-binding site of neuropilin-1

神经纤毛蛋白-1 精氨酸结合位点的结构和水化

Filipa Mota, Constantina Fotinou, Rohini R Rana, A W Edith Chan, Tamas Yelland, Mohamed T Arooz, Andrew P O'Leary, Jennie Hutton, Paul Frankel, Ian Zachary, David Selwood, Snezana Djordjevic