日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

一种用于心脏保护和神经再生的PI3Kα小分子激活剂

Grace Q Gong ,Benoit Bilanges ,Ben Allsop ,Glenn R Masson ,Victoria Roberton ,Trevor Askwith ,Sally Oxenford ,Ralitsa R Madsen ,Sarah E Conduit ,Dom Bellini ,Martina Fitzek ,Matt Collier ,Osman Najam ,Zhenhe He ,Ben Wahab ,Stephen H McLaughlin ,A W Edith Chan ,Isabella Feierberg ,Andrew Madin ,Daniele Morelli ,Amandeep Bhamra ,Vanesa Vinciauskaite ,Karen E Anderson ,Silvia Surinova ,Nikos Pinotsis ,Elena Lopez-Guadamillas ,Matthew Wilcox ,Alice Hooper ,Chandni Patel ,Maria A Whitehead ,Tom D Bunney ,Len R Stephens ,Phillip T Hawkins ,Matilda Katan ,Derek M Yellon ,Sean M Davidson ,David M Smith ,James B Phillips ,Richard Angell ,Roger L Williams ,Bart Vanhaesebroeck

Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease

利用从头设计的抑制剂在视网膜疾病模型中验证GEF-H1的治疗效果

Clare Mills ,Sandra A Hemkemeyer ,Zerin Alimajstorovic ,Chantelle Bowers ,Malihe Eskandarpour ,John Greenwood ,Virginia Calder ,A W Edith Chan ,Paul J Gane ,David L Selwood ,Karl Matter ,Maria S Balda

Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1

血管内皮生长因子 B 衍生的肽与神经纤毛蛋白-1 有强效结合

Filipa Mota, Tamas Yelland, Jennie A Hutton, Jennifer Parker, Anastasia Patsiarika, A W Edith Chan, Andrew O'Leary, Constantina Fotinou, John F Martin, Ian C Zachary, Snezana Djordjevic, Paul Frankel, David L Selwood

Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells

小分子神经纤毛蛋白-1拮抗剂通过减少调节性T细胞中转化生长因子β(TGFβ)的产生,将抗血管生成和抗肿瘤活性与免疫调节相结合。

Jonathan Powell ,Filipa Mota ,David Steadman ,Christelle Soudy ,Jeremy T Miyauchi ,Stuart Crosby ,Ashley Jarvis ,Tifelle Reisinger ,Natalie Winfield ,Graham Evans ,Aled Finniear ,Tamas Yelland, Yi-Tai Chou ,A W Edith Chan ,Andrew O'Leary ,Lili Cheng ,Dan Liu ,Constantina Fotinou ,Carla Milagre ,John F Martin ,Haiyan Jia ,Paul Frankel ,Snezana Djordjevic ,Stella E Tsirka ,Ian C Zachary ,David L Selwood

Architecture and hydration of the arginine-binding site of neuropilin-1

神经纤毛蛋白-1 精氨酸结合位点的结构和水化

Filipa Mota, Constantina Fotinou, Rohini R Rana, A W Edith Chan, Tamas Yelland, Mohamed T Arooz, Andrew P O'Leary, Jennie Hutton, Paul Frankel, Ian Zachary, David Selwood, Snezana Djordjevic

Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

利用siRNA和小分子筛选在细胞中鉴定调控ATG4B活性的激酶和磷酸酶

Niccolo Pengo,Krisna Prak,Joana R Costa,Christin Luft,Alexander Agrotis,Jamie Freeman,Christina A Gewinner,A W Edith Chan,David L Selwood,Janos Kriston-Vizi,Robin Ketteler

IKKγ-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection

IKKγ-模拟肽阻断与卡波西肉瘤相关疱疹病毒感染相关的细胞凋亡抵抗

Louise C Briggs, A W Edith Chan, Christopher A Davis, Nicholas Whitelock, Hajira A Hotiana, Mehdi Baratchian, Claire Bagnéris, David L Selwood, Mary K Collins, Tracey E Barrett

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis

选择性抑制线粒体通透性转换孔可防止实验性多发性硬化症中的神经退行性病变

Justin Warne, Gareth Pryce, Julia M Hill, Xiao Shi, Felicia Lennerås, Fabiola Puentes, Maarten Kip, Laura Hilditch, Paul Walker, Michela I Simone, A W Edith Chan, Greg J Towers, Alun R Coker, Michael R Duchen, Gyorgy Szabadkai, David Baker, David L Selwood

Benzobisthiazoles Represent a Novel Scaffold for Kinase Inhibitors of CLK Family Members

苯并双噻唑是 CLK 家族成员激酶抑制剂的新型支架

Krisna Prak, Janos Kriston-Vizi, A W Edith Chan, Christin Luft, Joana R Costa, Niccolo Pengo, Robin Ketteler

Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis

咪唑-1-基乙基吲唑电压门控钠通道配体在多发性硬化症小鼠模型的视神经炎期间具有神经保护作用

Lorcan Browne, Katie Lidster, Sarah Al-Izki, Lisa Clutterbuck, Cristina Posada, A W Edith Chan, Dieter Riddall, John Garthwaite, David Baker, David L Selwood