文献库，生知库 | 链接生命科学的每一步

日期影响因子

Discovery of a pyridine-piperazine-based small molecule that enhances the activity of peptidase neurolysin

发现一种基于吡啶-哌嗪的小分子，可增强肽酶神经溶素的活性

期刊:Journal of Pharmacology and Experimental Therapeutics

影响因子:3.8

doi:10.1016/j.jpet.2026.103827

ElSayed ElZorkany, Heba; Kandil, Haya; Jayaraman, Srinidhi; Aly, Asmaa; Esfahani, Shiva Hadi; Patel, Dhavalkumar; Dannecker, Dennis; Maciag, Monika; Paul, Alyssa; Lowran, Kaitlin; Kumari, Shikha; Bose, Samik; Ostrov, David A; Wu, Colin G; Dickson, Alex; Abbruscato, Thomas J; Trippier, Paul C; Orlando, Benjamin J; Karamyan, Vardan T

发表日期：2026

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Brain endothelial permeability, transport, and flow assessed over 10 orders of magnitude using the in situ brain perfusion technique

利用原位脑灌注技术，评估了跨越 10 个数量级的脑内皮通透性、转运和血流。

期刊:Fluids and Barriers of the Cns

影响因子:6.2

doi:10.1186/s12987-024-00584-y

Smith, Quentin R; Mandula, Haritha; Parepally, Jagan Mohan R; Oki, Jun; Thomas, Fancy; Thorsheim, Helen R; Al-Ahmad, Abraham J; Abbruscato, Thomas J; Ask, Per; Hage, David S; Robinson, Peter J

发表日期：2024

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Imidazole Bioisostere Activators of Endopeptidase Neurolysin with Enhanced Potency and Metabolic Stability

咪唑类生物等排体激活内肽酶神经溶素，具有增强的效力和代谢稳定性

期刊:ACS Medicinal Chemistry Letters

doi:10.1021/acsmedchemlett.4c00009

Rahman, Md Shafikur; Hadi Esfahani, Shiva; Zhang, Yong; Queen, Aarfa; Aljarrah, Manar; Kandil, Haya; Baez, Andrew; Abbruscato, Thomas J; Karamyan, Vardan T; Trippier, Paul C

发表日期：2024

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Studies on diketopiperazine and dipeptide analogs as opioid receptor ligands

二酮哌嗪和二肽类似物作为阿片受体配体的研究

期刊:European Journal of Medicinal Chemistry

影响因子:5.9

doi:10.1016/j.ejmech.2023.115309

Shahbazi Nia, Siavash; Hossain, Mohammad Anwar; Ji, Guangchen; Jonnalagadda, Sravan K; Obeng, Samuel; Rahman, Md Ashrafur; Sifat, Ali Ehsan; Nozohouri, Saeideh; Blackwell, Collin; Patel, Dhavalkumar; Thompson, Jon; Runyon, Scott; Hiranita, Takato; McCurdy, Christopher R; McMahon, Lance; Abbruscato, Thomas J; Trippier, Paul C; Neugebauer, Volker; German, Nadezhda A

发表日期：2023

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Permeability of Metformin across an In Vitro Blood-Brain Barrier Model during Normoxia and Oxygen-Glucose Deprivation Conditions: Role of Organic Cation Transporters (Octs)

二甲双胍在常氧和缺氧缺糖条件下体外血脑屏障模型中的渗透性：有机阳离子转运体的作用（Octs）

期刊:Pharmaceutics

影响因子:5.5

doi:10.3390/pharmaceutics15051357

Sharma, Sejal; Zhang, Yong; Akter, Khondker Ayesha; Nozohouri, Saeideh; Archie, Sabrina Rahman; Patel, Dhavalkumar; Villalba, Heidi; Abbruscato, Thomas

发表日期：2023

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Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals

发现具有高血脑屏障通透性的新一代非肽类神经溶素激活剂：健康动物和中风动物的药代动力学研究

期刊:Pharmaceutical Research

影响因子:4.3

doi:10.1007/s11095-023-03619-5

Zhang, Yong; Sharma, Sejal; Jonnalagadda, Shirisha; Kumari, Shikha; Queen, Aarfa; Esfahani, Shiva Hadi; Archie, Sabrina Rahman; Nozohouri, Saeideh; Patel, Dhavalkumar; Trippier, Paul C; Karamyan, Vardan T; Abbruscato, Thomas J

发表日期：2023

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Correction: Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping

更正：星形胶质细胞血管紧张素转化酶 2 在 COVID-19 神经传播以及吸烟和电子烟诱发的神经炎症状态中的潜在作用

期刊:Fluids and Barriers of the Cns

影响因子:6.2

doi:10.1186/s12987-022-00388-y

Zhang, Yong; Archie, Sabrina Rahman; Ghanwatkar, Yashwardhan; Sharma, Sejal; Nozohouri, Saeideh; Burks, Elizabeth; Mdzinarishvili, Alexander; Liu, Zijuan; Abbruscato, Thomas J

细胞生物学

发表日期：2022

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Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes

缺血性脑卒中患者的脑能量代谢：吸烟和糖尿病的影响

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms23158512

Sifat, Ali Ehsan; Nozohouri, Saeideh; Archie, Sabrina Rahman; Chowdhury, Ekram Ahmed; Abbruscato, Thomas J

发表日期：2022

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Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: A pharmacokinetic and pharmacodynamics perspective

生物学因素影响尼古丁和烟草烟雾的神经血管毒性：药代动力学和药效学视角

期刊:Neurotoxicology

影响因子:3.9

doi:10.1016/j.neuro.2022.02.002

Archie, Sabrina Rahman; Sharma, Sejal; Burks, Elizabeth; Abbruscato, Thomas

发表日期：2022

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Structure-activity relationship studies of functionalized aromatic peptidomimetics as neurolysin activators

功能化芳香肽模拟物作为神经溶素激活剂的构效关系研究

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2022.128669

Rahman, Md Shafikur; Esfahani, Shiva Hadi; Nozohouri, Saeideh; Kumari, Shikha; Kocot, Joanna; Zhang, Yong; Abbruscato, Thomas J; Karamyan, Vardan T; Trippier, Paul C

发表日期：2022

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