Boswellic Acid and Low-Dose Radiation Attenuate Hepatic Carcinogenesis induced in Rats by Suppressing NF-κB/TNF-α/MAPK Signaling, Blocking Angiogenesis, and Inducing Apoptosis via JAK/STAT3 Downstream Granzyme-B and Caspase-3 Pathways
乳香酸和低剂量辐射通过抑制NF-κB/TNF-α/MAPK信号通路、阻断血管生成以及通过JAK/STAT3下游颗粒酶B和Caspase-3通路诱导细胞凋亡，从而减轻大鼠肝癌的发生。
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c03158
Vagadia, Purav P; Izquierdo-Ferrer, Javier; Mazewski, Candice; Blyth, Gavin; Beauchamp, Elspeth M; Clutter, Matthew R; Stern, Charlotte L; Mishra, Rama K; Nahotko, Dominik; Small, Sara; Eckerdt, Frank; Platanias, Leonidas C; Schiltz, Gary E; Elbakary, Nermeen M; Abdel-Rafei, Mohamed Khairy; Kayed, Azza E; Elbahnasawy, Mostafa A; Mansour, Mansour I
肿瘤
凋亡
表观遗传
肿瘤免疫
Apoptosis
JAK/STAT
信号转导
NF-κB
Rat
MAPK/ERK
STAT3
TNF-α
Angiogenesis
肝癌
细胞生物学
血管生成
