日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Dietary Yam (Dioscorea opposita Thunb.) Ameliorates Parkinson’s Disease in Mice via Gut Microbiota-Driven Mitochondrial Improvement and Neuroinflammation Inhibition

食用山药（Dioscorea opposita Thunb.）通过肠道菌群驱动的线粒体改善和神经炎症抑制来改善小鼠帕金森病

期刊:Neurology
影响因子:8.5
doi:10.1212/WNL.0000000000214614
Kumar, Rakesh; Gravett, Stephanie; Jelic, Vesna; Lange, Johannes; Oftedal, Linn; Ciullini, Arianna; Bacınoğlu, Merve Begüm; De Luca, Chiara Maria Giulia; Hamied, Lola; Birck, Catherine; Blanc, Frederic; Hoede, Patty L; Lemstra, Afina W; Gonzalez, Maria Camila; Aarsland, Dag; Teunissen, Charlotte E; Bousiges, Olivier; Moda, Fabio; Maple-Grødem, Jodi; Abelein, Axel; Ferreira, Daniel; Zhang, Shuqing; Pan, Wenjia; Ma, Chen; Luo, Yinghua; Dong, Li; Ji, Junfu; Ma, Lingjun; Li, Daotong; Chen, Fang
线粒体
微生物学
炎症/感染
神经科学
神经炎症
肠道菌群
帕金森
炎症
发表日期：2026
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Chaperone-Mediated Regulation of Tau Phase Separation, Fibrillation, and Toxicity

分子伴侣介导的Tau蛋白相分离、纤维化和毒性调控

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c01369
Mörman, Cecilia; Leppert, Axel; Pizzirusso, Giusy; Zheng, Zihan; Sun, Xun; Kumar, Rakesh; Biverstål, Henrik; Landreh, Michael; Johansson, Jan; Arroyo-Garcia, Luis Enrique; Luo, Jinghui; Chen, Gefei; Abelein, Axel
信号转导
相分离
毒理研究
发表日期：2025
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Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor

幽门螺杆菌CagA蛋白是一种强效且广谱的淀粉样蛋白抑制剂。

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.ads7525
Jin, Zhen; Olsen, William Pallisgaard; Mörman, Cecilia; Leppert, Axel; Kumar, Rakesh; Møllebjerg, Andreas; Nielsen, Lotte Godthaab; Moshynets, Olena V; Frasinyuk, Mykhaylo S; Elosua, Jokin Yeregui; Ferreira, Daniel; Abelein, Axel; Landreh, Michael; Knight, Stefan D; Johansson, Jan; Otzen, Daniel E; Chen, Gefei
发表日期：2025
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Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain

识别抗淀粉样蛋白伴侣样 BRICHOS 结构域阻断的 Aβ42 原纤维上的潜在聚集热点

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-024-45192-4
Rakesh Kumar, Tanguy Le Marchand, Laurène Adam, Raitis Bobrovs, Gefei Chen, Jēkabs Fridmanis, Nina Kronqvist, Henrik Biverstål, Kristaps Jaudzems, Jan Johansson, Guido Pintacuda, Axel Abelein
发表日期：2024
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Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS

分子伴侣结构域 Bri2 BRICHOS 对 α-突触核蛋白寡聚体的生成和毒性有特异性的抑制作用

期刊:Protein Science
影响因子:4.5
doi:10.1002/pro.5091
Laurène Adam, Rakesh Kumar, Luis Enrique Arroyo-Garcia, Willem Hendrik Molenkamp, Jan Stanislaw Nowak, Hannah Klute, Azad Farzadfard, Rami Alkenayeh, Janni Nielsen, Henrik Biverstål, Daniel E Otzen, Jan Johansson, Axel Abelein
毒理研究
神经科学
发表日期：2024
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Molecular basis for different substrate-binding sites and chaperone functions of the BRICHOS domain

BRICHOS 结构域不同底物结合位点和分子伴侣功能的分子基础

期刊:Protein Science
影响因子:4.5
doi:10.1002/pro.5063
Gefei Chen, Yu Wang, Zihan Zheng, Wangshu Jiang, Axel Leppert, Xueying Zhong, Anna Belorusova, Gregg Siegal, Caroline Jegerschöld, Philip J B Koeck, Axel Abelein, Hans Hebert, Stefan D Knight, Jan Johansson
发表日期：2024
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Intravenous treatment with a molecular chaperone designed against β-amyloid toxicity improves Alzheimer's disease pathology in mouse models

使用针对 β-淀粉样蛋白毒性的分子伴侣进行静脉注射治疗可改善小鼠模型中的阿尔茨海默病病理

期刊:Molecular Therapy
影响因子:12.1
doi:10.1016/j.ymthe.2022.08.010
Shaffi Manchanda, Lorena Galan-Acosta, Axel Abelein, Simone Tambaro, Gefei Chen, Per Nilsson, Jan Johansson
阿尔茨海默症
毒理研究
发表日期：2023
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A new kid in the folding funnel: Molecular chaperone activities of the BRICHOS domain

折叠漏斗中的新成员：BRICHOS结构域的分子伴侣活性

期刊:Protein Science
影响因子:5.2
doi:10.1002/pro.4645
Leppert, Axel; Poska, Helen; Landreh, Michael; Abelein, Axel; Chen, Gefei; Johansson, Jan
发表日期：2023
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Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation

BRICHOS 结构域中的短疏水环基序决定了分子伴侣对抗无定形蛋白质聚集的活性，但不对抗淀粉样蛋白的形成

期刊:Communications Biology
影响因子:5.2
doi:10.1038/s42003-023-04883-2
Gefei Chen #, Axel Leppert #, Helen Poska, Harriet E Nilsson, Carlos Piedrafita Alvira, Xueying Zhong, Philip Koeck, Caroline Jegerschöld, Axel Abelein, Hans Hebert, Jan Johansson
信号转导
发表日期：2023
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Misfolded alpha-synuclein detection by RT-QuIC in dementia with lewy bodies: a systematic review and meta-analysis

利用RT-QuIC检测路易体痴呆症中错误折叠的α-突触核蛋白：系统评价和荟萃分析

期刊:Frontiers in Molecular Biosciences
影响因子:4
doi:10.3389/fmolb.2023.1193458
Peña-Bautista, Carmen; Kumar, Rakesh; Baquero, Miguel; Johansson, Jan; Cháfer-Pericás, Consuelo; Abelein, Axel; Ferreira, Daniel
神经科学
发表日期：2023
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