日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

3D-super-enhancers are condensate-associated cis-regulatory communities

3D超增强子是与凝聚体相关的顺式调控群落

Lv, Jie; Maher, Kelsey A; Dong, Li; Valentine, Virginia; Staller, Seth; Veluchamy, Alaguraj; Tian, Li; Kim, Yuna; Ju, Bensheng; Valentine, Marcus; Easton, John; Pounds, Stanley B; Burden, Steven; Abraham, Brian J

Specific oncogene activation of the cell of origin in mucosal melanoma

黏膜黑色素瘤起源细胞的特定癌基因激活

Babu, Swathy; Chen, Jiajia; Baron, Chloé S; Sun, Kaiwen; Robitschek, Emily; McConnell, Alicia M; Wu, Constance; Dedeilia, Aikaterini; Sade-Feldman, Moshe; Modhurima, Rodsy; Manos, Michael P; Chen, Kevin Y; Cox, Anna M; Ludwig, Calvin G; Kellis, Manolis; Buchbinder, Elizabeth I; Hacohen, Nir; Yang, Jiekun; Boland, Genevieve M; Abraham, Brian J; Liu, David; Zon, Leonard I; Insco, Megan L

Generation of an iPSC-derived alveolar rhabdomyosarcoma cell line during directed endothelial differentiation.

在定向内皮分化过程中生成 iPSC 衍生的肺泡横纹肌肉瘤细胞系。

Larsen Randolph K 4th, Searcy Madeline B, Stevens Bradley T, Gadek Katherine E, Zhang Yang, Abraham Brian J, Hatley Mark E

KAT6A/B inhibition synergizes with retinoic acid and enhances the efficacy of GD2-targeted immunotherapy in neuroblastoma

KAT6A/B抑制剂与维甲酸具有协同作用,可增强GD2靶向免疫疗法在神经母细胞瘤中的疗效。

Weichert-Leahey, Nina; Berezovskaya, Alla; Zimmerman, Mark W; Alvarez-Calderon, Francesca; Winschel, Marlana; Salhotra, Silvi; Mabe, Nathaniel; Perez-Atayde, Antonio; Vitorino, Francisca N de L; Garcia, Benjamin; Gerdemann, Ulrike; Stegmaier, Kimberly; Durbin, Adam D; Oldridge, Derek A; Abraham, Brian J; Look, A Thomas

Multitargeted Reduction of Inflammation and Atherosclerosis in Tet2 -deficient CHIP via XPO1 Inhibition and Atf3 restoration

通过抑制XPO1和恢复Atf3,多靶点降低Tet2缺陷型CHIP的炎症和动脉粥样硬化

Prutsch, Nicole; Vromman, Amélie; Leeper, Brittaney; Chen, Mengyu; Keating, Julia; He, Shuning; Berezovskaya, Alla; Ren, Siyang; Gomes, Mariana Janini; Folco, Eduardo J; Rauch, Philipp J; Gokhale, Prafulla C; Zimmerman, Mark W; Neuberg, Donna S; Abraham, Brian J; Libby, Peter; Look, A Thomas

Oncogenic CDK13 mutations impede nuclear RNA surveillance

致癌性 CDK13 突变会阻碍核 RNA 监视

Insco, Megan L; Abraham, Brian J; Dubbury, Sara J; Kaltheuner, Ines H; Dust, Sofia; Wu, Constance; Chen, Kevin Y; Liu, David; Bellaousov, Stanislav; Cox, Anna M; Martin, Benjamin J E; Zhang, Tongwu; Ludwig, Calvin G; Fabo, Tania; Modhurima, Rodsy; Esgdaille, Dakarai E; Henriques, Telmo; Brown, Kevin M; Chanock, Stephen J; Geyer, Matthias; Adelman, Karen; Sharp, Phillip A; Young, Richard A; Boutz, Paul L; Zon, Leonard I

Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state

神经母细胞瘤的遗传易感性源于一种促进肾上腺素能细胞状态的调控多态性。

Weichert-Leahey, Nina; Shi, Hui; Tao, Ting; Oldridge, Derek A; Durbin, Adam D; Abraham, Brian J; Zimmerman, Mark W; Zhu, Shizhen; Wood, Andrew C; Reyon, Deepak; Joung, J Keith; Young, Richard A; Diskin, Sharon J; Maris, John M; Look, A Thomas

The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes

核受体THRB促进人类多能干细胞分化为更成熟的肝细胞。

Ma, Haiting; Zwaan, Esmée de; Guo, Yang Eric; Cejas, Paloma; Thiru, Prathapan; van de Bunt, Martijn; Jeppesen, Jacob F; Syamala, Sudeepa; Dall'Agnese, Alessandra; Abraham, Brian J; Fu, Dongdong; Garrett-Engele, Carrie; Lee, Tong Ihn; Long, Henry W; Griffith, Linda G; Young, Richard A; Jaenisch, Rudolf

Intrinsic transcriptional heterogeneity in neuroblastoma guides mechanistic and therapeutic insights

神经母细胞瘤内在的转录异质性为机制和治疗提供了新的见解

Shendy, Noha A M; Zimmerman, Mark W; Abraham, Brian J; Durbin, Adam D

BRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation

BRD2 与 BRD3 相互作用,促进 Pol II 转录起始和延伸,从而使启动子做好细胞分化的准备。

Wang, Chenlu; Xu, Qiqin; Zhang, Xianhong; Day, Daniel S; Abraham, Brian J; Lun, Kehuan; Chen, Liang; Huang, Jie; Ji, Xiong