日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.

利用 iPSC 衍生神经元进行 CRISPR 筛选揭示了 tau 蛋白稳态的原理。

Samelson Avi J, Ariqat Nabeela, McKetney Justin, Rohanitazangi Gita, Parra Bravo Celeste, Bose Rudra S, Travaglini Kyle J, Lam Victor L, Goodness Darrin, Ta Thomas, Dixon Gary, Marzette Emily, Jin Julianne, Tian Ruilin, Tse Eric, Abskharon Romany, Pan Henry S, Carroll Emma C, Lawrence Rosalie E, Gestwicki Jason E, Rexach Jessica E, Eisenberg David S, Kanaan Nicholas M, Southworth Daniel R, Gross John D, Gan Li, Swaney Danielle L, Kampmann Martin

Structural evidence that RNA contributes to polymorphism of tau amyloid fibrils.

结构证据表明 RNA 参与了 tau 淀粉样蛋白原纤维的多态性。

Abskharon Romany, Jiang Yi Xiao, Sawaya Michael R, Ge Peng, Zhang Jeffrey, Boyer David R, Dolinsky Joshua L, Pi Justin, Cascio Duilio, Guo Feng, Eisenberg David S

How short peptides disassemble tau fibrils in Alzheimer's disease.

短肽如何分解阿尔茨海默病中的tau蛋白原纤维

Hou Ke, Ge Peng, Sawaya Michael R, Lutter Liisa, Dolinsky Joshua L, Yang Yuan, Jiang Yi Xiao, Boyer David R, Cheng Xinyi, Pi Justin, Zhang Jeffrey, Lu Jiahui, Abskharon Romany, Yang Shixin, Yu Zhiheng, Feigon Juli, Eisenberg David S

Liganded magnetic nanoparticles for magnetic resonance imaging of α-synuclein.

用于α-突触核蛋白磁共振成像的配体磁性纳米粒子

Pan Hope, Balbirnie Melinda, Hou Ke, Sta Maria Naomi S, Sahay Shruti, Denver Paul, Lepore Stefano, Jones Mychica, Zuo Xiaohong, Zhu Chunni, Mirbaha Hilda, Shahpasand-Kroner Hedieh, Mekkittikul Marisa, Lu Jiahui, Hu Carolyn J, Cheng Xinyi, Abskharon Romany, Sawaya Michael R, Williams Christopher K, Vinters Harry V, Jacobs Russell E, Harris Neil G, Cole Gregory M, Frautschy Sally A, Eisenberg David S

Investigating the In Vivo Effects of Anti-Prion Protein Nanobodies on Prion Disease with AAV Vector

利用AAV载体研究抗朊病毒蛋白纳米抗体对朊病毒疾病的体内作用

Jingjing Zhang ,Mengfei Wang ,Dan Wang ,Xiangyi Zhang ,Yue Ma ,Els Pardon ,Jan Steyaert ,Romany Abskharon ,Fei Wang ,Jiyan Ma

D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease

肽磁性纳米粒子碎裂 tau 纤维并挽救阿尔茨海默病小鼠模型中的行为缺陷

Ke Hou, Hope Pan, Hedieh Shahpasand-Kroner, Carolyn Hu, Romany Abskharon, Paul Seidler, Marisa Mekkittikul, Melinda Balbirnie, Carter Lantz, Michael R Sawaya, Joshua L Dolinsky, Mychica Jones, Xiaohong Zuo, Joseph A Loo, Sally Frautschy, Greg Cole, David S Eisenberg

Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation

hnRNPA2低复杂度结构域D290V突变体的冷冻电镜结构揭示了D290V如何影响相分离和聚集。

Lu, Jiahui; Ge, Peng; Sawaya, Michael R; Hughes, Michael P; Boyer, David R; Cao, Qin; Abskharon, Romany; Cascio, Duilio; Tayeb-Fligelman, Einav; Eisenberg, David S

Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

SARS-CoV-2 核衣壳蛋白的低复杂度结构域形成淀粉样蛋白原纤维

Einav Tayeb-Fligelman, Jeannette T Bowler, Christen E Tai, Michael R Sawaya, Yi Xiao Jiang, Gustavo Garcia Jr, Sarah L Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M Seidler, Jiahui Lu, Gregory M Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R Boyer, Yan Li, Daniel H

Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method

TFG 蛋白突变体的纤维结构通过 IMPAcT 方法验证了 TFG 为疾病相关的淀粉样蛋白

Gregory M Rosenberg, Romany Abskharon, David R Boyer, Peng Ge, Michael R Sawaya, David S Eisenberg

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

iPSC 衍生神经元中的 CRISPR 筛选揭示了 tau 蛋白稳态的原理

Avi J Samelson, Nabeela Ariqat, Justin McKetney, Gita Rohanitazangi, Celeste Parra Bravo, Darrin Goodness, Ruilin Tian, Parker Grosjean, Romany Abskharon, David Eisenberg, Nicholas M Kanaan, Li Gan, Carlo Condello, Danielle L Swaney, Martin Kampmann