日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.

利用 iPSC 衍生神经元进行 CRISPR 筛选揭示了 tau 蛋白稳态的原理。

Samelson Avi J, Ariqat Nabeela, McKetney Justin, Rohanitazangi Gita, Parra Bravo Celeste, Bose Rudra S, Travaglini Kyle J, Lam Victor L, Goodness Darrin, Ta Thomas, Dixon Gary, Marzette Emily, Jin Julianne, Tian Ruilin, Tse Eric, Abskharon Romany, Pan Henry S, Carroll Emma C, Lawrence Rosalie E, Gestwicki Jason E, Rexach Jessica E, Eisenberg David S, Kanaan Nicholas M, Southworth Daniel R, Gross John D, Gan Li, Swaney Danielle L, Kampmann Martin

Structural evidence that RNA contributes to polymorphism of tau amyloid fibrils.

结构证据表明 RNA 参与了 tau 淀粉样蛋白原纤维的多态性。

Abskharon Romany, Jiang Yi Xiao, Sawaya Michael R, Ge Peng, Zhang Jeffrey, Boyer David R, Dolinsky Joshua L, Pi Justin, Cascio Duilio, Guo Feng, Eisenberg David S

How short peptides disassemble tau fibrils in Alzheimer's disease.

短肽如何分解阿尔茨海默病中的tau蛋白原纤维

Hou Ke, Ge Peng, Sawaya Michael R, Lutter Liisa, Dolinsky Joshua L, Yang Yuan, Jiang Yi Xiao, Boyer David R, Cheng Xinyi, Pi Justin, Zhang Jeffrey, Lu Jiahui, Abskharon Romany, Yang Shixin, Yu Zhiheng, Feigon Juli, Eisenberg David S

Liganded magnetic nanoparticles for magnetic resonance imaging of α-synuclein.

用于α-突触核蛋白磁共振成像的配体磁性纳米粒子

Pan Hope, Balbirnie Melinda, Hou Ke, Sta Maria Naomi S, Sahay Shruti, Denver Paul, Lepore Stefano, Jones Mychica, Zuo Xiaohong, Zhu Chunni, Mirbaha Hilda, Shahpasand-Kroner Hedieh, Mekkittikul Marisa, Lu Jiahui, Hu Carolyn J, Cheng Xinyi, Abskharon Romany, Sawaya Michael R, Williams Christopher K, Vinters Harry V, Jacobs Russell E, Harris Neil G, Cole Gregory M, Frautschy Sally A, Eisenberg David S

Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation

hnRNPA2低复杂度结构域D290V突变体的冷冻电镜结构揭示了D290V如何影响相分离和聚集。

Lu, Jiahui; Ge, Peng; Sawaya, Michael R; Hughes, Michael P; Boyer, David R; Cao, Qin; Abskharon, Romany; Cascio, Duilio; Tayeb-Fligelman, Einav; Eisenberg, David S

Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro

基于结构的体外小分子解聚剂筛选,用于研究阿尔茨海默病组织来源的tau蛋白纤维。

Seidler, Paul M; Murray, Kevin A; Boyer, David R; Ge, Peng; Sawaya, Michael R; Hu, Carolyn J; Cheng, Xinyi; Abskharon, Romany; Pan, Hope; DeTure, Michael A; Williams, Christopher K; Dickson, Dennis W; Vinters, Harry V; Eisenberg, David S

De novo designed protein inhibitors of amyloid aggregation and seeding

从头设计淀粉样蛋白聚集和播种的蛋白质抑制剂

Murray, Kevin A; Hu, Carolyn J; Griner, Sarah L; Pan, Hope; Bowler, Jeannette T; Abskharon, Romany; Rosenberg, Gregory M; Cheng, Xinyi; Seidler, Paul M; Eisenberg, David S

Bioinformatic identification of previously unrecognized amyloidogenic proteins

利用生物信息学方法鉴定先前未被识别的淀粉样蛋白

Rosenberg, Gregory M; Murray, Kevin A; Salwinski, Lukasz; Hughes, Michael P; Abskharon, Romany; Eisenberg, David S

Correction to: In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrP(V180I) Mutation

更正:来自蛋白酶敏感性可变朊病毒病和与 PrP(V180I) 突变相关的家族性克雅氏病的糖型缺陷朊病毒的体外播种活性

Wang, Zerui; Yuan, Jue; Shen, Pingping; Abskharon, Romany; Lang, Yue; Dang, Johnny; Adornato, Alise; Xu, Ling; Chen, Jiafeng; Feng, Jiachun; Moudjou, Mohammed; Kitamoto, Tetsuyuki; Lee, Hyoung-Gon; Kim, Yong-Sun; Langeveld, Jan; Appleby, Brian; Ma, Jiyan; Kong, Qingzhong; Petersen, Robert B; Zou, Wen-Quan; Cui, Li

In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrP(V180I) Mutation

与 PrP(V180I) 突变相关的可变蛋白酶敏感性朊病毒病和家族性克雅氏病中糖型缺陷朊病毒的体外播种活性

Wang, Zerui; Yuan, Jue; Shen, Pingping; Abskharon, Romany; Lang, Yue; Dang, Johnny; Adornato, Alise; Xu, Ling; Chen, Jiafeng; Feng, Jiachun; Moudjou, Mohammed; Kitamoto, Tetsuyuki; Lee, Hyoung-Gon; Kim, Yong-Sun; Langeveld, Jan; Appleby, Brian; Ma, Jiyan; Kong, Qingzhong; Petersen, Robert B; Zou, Wen-Quan; Cui, Li