日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A rapid combinatorial assembly method for gene cluster characterisation illuminates glidobactin biosynthesis

用于基因簇表征的快速组合组装方法揭示了胶杆菌素的生物合成

期刊:Synthetic and Systems Biotechnology
影响因子:4.4
doi:10.1016/j.synbio.2025.09.010
Calcott, Mark J; Kröger, Jonas; Ackerley, David F
发表日期：2026
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Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623

对一种经工程改造以提高5-硝基咪唑PET探针SN33623活化能力的硝基还原酶进行结构评估

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms25126593
Sharrock, Abigail V; Mumm, Jeff S; Williams, Elsie M; Čėnas, Narimantas; Smaill, Jeff B; Patterson, Adam V; Ackerley, David F; Bagdžiūnas, Gintautas; Arcus, Vickery L
发表日期：2024
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A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.

一种促进捕获基因高水平表达的宏基因组文库克隆策略，可实现高效的功能筛选

期刊:Cell Chemical Biology
影响因子:7.2
doi:10.1016/j.chembiol.2023.10.001
Rich Michelle H, Sharrock Abigail V, Mulligan Timothy S, Matthews Frazer, Brown Alistair S, Lee-Harwood Hannah R, Williams Elsie M, Copp Janine N, Little Rory F, Francis Jenni J B, Horvat Claire N, Stevenson Luke J, Owen Jeremy G, Saxena Meera T, Mumm Jeff S, Ackerley David F
其它
发表日期：2023
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A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening

一种促进捕获基因高水平表达的宏基因组文库克隆策略，可实现高效的功能筛选。

期刊:
影响因子:
doi:10.1101/2023.03.24.534183
Rich, Michelle H; Sharrock, Abigail V; Mulligan, Timothy S; Matthews, Frazer; Brown, Alistair S; Lee-Harwood, Hannah R; Williams, Elsie M; Copp, Janine N; Little, Rory F; Francis, Jenni Jb; Horvat, Claire N; Stevenson, Luke J; Owen, Jeremy G; Saxena, Meera T; Mumm, Jeff S; Ackerley, David F
发表日期：2023
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Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

对用于癌症基因治疗的亲脂性硝基芳香族前药系列进行构效关系研究

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph15020185
Ashoorzadeh, Amir; Mowday, Alexandra M; Guise, Christopher P; Silva, Shevan; Bull, Matthew R; Abbattista, Maria R; Copp, Janine N; Williams, Elsie M; Ackerley, David F; Patterson, Adam V; Smaill, Jeff B
肿瘤
基因治疗
肿瘤免疫
发表日期：2022
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Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the Essential Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT

抑制靛蓝素合成作为高通量比色筛选靶向结核分枝杆菌必需磷酸泛酰巯基转移酶 PptT 的抗生素

期刊:Pharmaceutics
影响因子:5.5
doi:10.3390/pharmaceutics13071066
Brown, Alistair S; Owen, Jeremy G; Jung, James; Baker, Edward N; Ackerley, David F
发表日期：2021
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Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3

通过开发一种对人醛酮还原酶1C3有氧代谢具有抗性的类似物，恢复生物还原前药PR-104的肿瘤选择性

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph14121231
Abbattista, Maria R; Ashoorzadeh, Amir; Guise, Christopher P; Mowday, Alexandra M; Mittra, Rituparna; Silva, Shevan; Hicks, Kevin O; Bull, Matthew R; Jackson-Patel, Victoria; Lin, Xiaojing; Prosser, Gareth A; Lambie, Neil K; Dachs, Gabi U; Ackerley, David F; Smaill, Jeff B; Patterson, Adam V
Human
肿瘤
肿瘤免疫
代谢
发表日期：2021
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Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway

Metathramycin 是一种新的生物活性金霉素，它是通过异源表达宏基因组衍生的生物合成途径发现的。

期刊:RSC Chemical Biology
影响因子:3.1
doi:10.1039/d0cb00228c
Stevenson, Luke J; Bracegirdle, Joe; Liu, Liwei; Sharrock, Abigail V; Ackerley, David F; Keyzers, Robert A; Owen, Jeremy G
发表日期：2021
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Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues

通过活性位点残基的质量随机化揭示获得新的酶功能的细胞内复杂性

期刊:Elife
影响因子:6.4
doi:10.7554/eLife.59081
Hall, Kelsi R; Robins, Katherine J; Williams, Elsie M; Rich, Michelle H; Calcott, Mark J; Copp, Janine N; Little, Rory F; Schwörer, Ralf; Evans, Gary B; Patrick, Wayne M; Ackerley, David F
细胞生物学
发表日期：2020
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Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

机制理解有助于合理设计水杨酰苯胺类药物联合疗法治疗革兰氏阴性菌感染

期刊:mBio
影响因子:4.7
doi:10.1128/mBio.02068-20
Copp, Janine N; Pletzer, Daniel; Brown, Alistair S; Van der Heijden, Joris; Miton, Charlotte M; Edgar, Rebecca J; Rich, Michelle H; Little, Rory F; Williams, Elsie M; Hancock, Robert E W; Tokuriki, Nobuhiko; Ackerley, David F
炎症/感染
发表日期：2020
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