日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells

结合多维单细胞蛋白质和RNA谱分析,可以解析胸腺上皮细胞的细胞和功能异质性。

Fabian Klein ,Clara Veiga-Villauriz ,Anastasiya Börsch ,Stefano Maio ,Sam Palmer ,Fatima Dhalla ,Adam E Handel ,Saulius Zuklys ,Irene Calvo-Asensio ,Lucas Musette ,Mary E Deadman ,Andrea J White ,Beth Lucas ,Graham Anderson ,Georg A Holländer

Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment

神经嵴-间充质轴在胸腺微环境形成中的发育动态

Adam E Handel ,Stanley Cheuk ,Fatima Dhalla ,Stefano Maio ,Tania Hübscher ,Ioanna Rota ,Mary E Deadman ,Olov Ekwall ,Matthias Lütolf ,Kenneth Weinberg ,Georg Holländer

Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer's disease mouse models

脂多糖明显改变人类小胶质细胞转录组,使其类似于阿尔茨海默病小鼠模型中的小胶质细胞

Jimena Monzón-Sandoval, Elena Burlacu, Devika Agarwal, Adam E Handel, Liting Wei, John Davis, Sally A Cowley, M Zameel Cader, Caleb Webber

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

FOXN1形成高级核凝聚体,这些凝聚体因突变而发生位移,从而导致免疫缺陷。

Ioanna A Rota ,Adam E Handel ,Stefano Maio ,Fabian Klein ,Fatima Dhalla ,Mary E Deadman ,Stanley Cheuk ,Joseph A Newman ,Yale S Michaels ,Saulius Zuklys ,Nicolas Prevot ,Philip Hublitz ,Philip D Charles ,Athina Soragia Gkazi ,Eleni Adamopoulou ,Waseem Qasim ,Edward Graham Davies ,Imelda Hanson ,Alistair T Pagnamenta ,Carme Camps ,Helene M Dreau ,Andrea White ,Kieran James ,Roman Fischer ,Opher Gileadi ,Jenny C Taylor ,Tudor Fulga ,B Christoffer Lagerholm ,Graham Anderson ,Erdinc Sezgin ,Georg A Holländer

Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories

转录因子的靶向单细胞 RNA 测序增强了细胞类型和轨迹的识别

Alexandra Pokhilko, Adam E Handel, Fabiola Curion, Viola Volpato, Emma S Whiteley, Sunniva Bøstrand, Sarah E Newey, Colin J Akerman, Caleb Webber, Michael B Clark, Rory Bowden, M Zameel Cader

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

伴侣蛋白 CCT8 控制着对 T 细胞成熟、选择和功能至关重要的蛋白质稳态

Bergithe E Oftedal #, Stefano Maio #, Adam E Handel, Madeleine P J White, Duncan Howie, Simon Davis, Nicolas Prevot, Ioanna A Rota, Mary E Deadman, Benedikt M Kessler, Roman Fischer, Nikolaus S Trede, Erdinc Sezgin, Rick M Maizels, Georg A Holländer1

Ageing compromises mouse thymus function and remodels epithelial cell differentiation

衰老会损害小鼠胸腺功能并重塑上皮细胞分化。

Jeanette Baran-Gale # ,Michael D Morgan # ,Stefano Maio ,Fatima Dhalla ,Irene Calvo-Asensio ,Mary E Deadman ,Adam E Handel ,Ashley Maynard ,Steven Chen ,Foad Green ,Rene V Sit ,Norma F Neff ,Spyros Darmanis ,Weilun Tan ,Andy P May ,John C Marioni ,Chris P Ponting ,Georg A Holländer

Keratinocyte growth factor impairs human thymic recovery from lymphopenia

角质形成细胞生长因子损害人类胸腺淋巴细胞减少症的恢复

Alasdair J Coles, Laura Azzopardi, Onajite Kousin-Ezewu, Harpreet Kaur Mullay, Sara Aj Thompson, Lorna Jarvis, Jessica Davies, Sarah Howlett, Daniel Rainbow, Judith Babar, Timothy J Sadler, J William L Brown, Edward Needham, Karen May, Zoya G Georgieva, Adam E Handel, Stefano Maio, Mary Deadman, Ioa

Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development

全面分析胸腺上皮细胞发育过程中组织特异性抗原表达的染色质结构

Adam E Handel ,Noriko Shikama-Dorn ,Saule Zhanybekova ,Stefano Maio ,Annina N Graedel ,Saulius Zuklys ,Chris P Ponting ,Georg A Holländer

Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics

通过单细胞转录组学评估诱导多能干细胞衍生的皮质神经元与原发组织和皮质层特征的相似性

Adam E Handel, Satyan Chintawar, Tatjana Lalic, Emma Whiteley, Jane Vowles, Alice Giustacchini, Karene Argoud, Paul Sopp, Mahito Nakanishi, Rory Bowden, Sally Cowley, Sarah Newey, Colin Akerman, Chris P Ponting, M Zameel Cader