日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

锌转运蛋白 SLC39A5 的基因失活可改善肥胖环境中的肝功能和高血糖

Shek Man Chim, Kristen Howell, John Dronzek, Weizhen Wu, Cristopher Van Hout, Manuel A R Ferreira, Bin Ye, Alexander Li, Susannah Brydges, Vinayagam Arunachalam, Anthony Marcketta, Adam E Locke, Jonas Bovijn, Niek Verweij, Tanima De, Luca Lotta, Lyndon Mitnaul, Michelle LeBlanc, Regeneron Genetics C

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

全基因组关联荟萃分析确定了腹主动脉瘤的风险位点,并强调 PCSK9 是治疗靶点

Tanmoy Roychowdhury #, Derek Klarin #, Michael G Levin #, Joshua M Spin, Yae Hyun Rhee, Alicia Deng, Colwyn A Headley, Noah L Tsao, Corry Gellatly, Verena Zuber, Fred Shen, Whitney E Hornsby, Ina Holst Laursen, Shefali S Verma, Adam E Locke, Gudmundur Einarsson, Gudmar Thorleifsson, Sarah E Graham, 

Heterozygous variants of CLPB are a cause of severe congenital neutropenia

CLPB的杂合变异是严重先天性中性粒细胞减少症的病因之一。

Julia T Warren ,Ryan R Cupo ,Peeradol Wattanasirakul ,David H Spencer ,Adam E Locke ,Vahagn Makaryan ,Audrey Anna Bolyard ,Merideth L Kelley ,Natalie L Kingston ,James Shorter ,Christine Bellanné-Chantelot ,Jean Donadieu ,David C Dale ,Daniel C Link

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

与体重指数相关的蛋白质变异暗示控制肥胖能量摄入和消耗的途径

Valérie Turcot #, Yingchang Lu #, Heather M Highland #, Claudia Schurmann #, Anne E Justice #, Rebecca S Fine #, Jonathan P Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff, Xiuqing Guo, Audrey E Hendricks, Tugce Karaderi, Adelheid Lempradl, Adam E Locke, Anubha Mahajan, Eirini Marouli, Suthesh Si

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

芬兰人群中富集的低频失活 AKT2 变体与空腹胰岛素水平和 2 型糖尿病风险相关

Alisa Manning, Heather M Highland, Jessica Gasser, Xueling Sim, Taru Tukiainen, Pierre Fontanillas, Niels Grarup, Manuel A Rivas, Anubha Mahajan, Adam E Locke, Pablo Cingolani, Tune H Pers, Ana Viñuela, Andrew A Brown, Ying Wu, Jason Flannick, Christian Fuchsberger, Eric R Gamazon, Kyle J Gaulton, H

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

影响血糖特征的 G6PC2 编码变体的鉴定和功能表征确定了 G6PC2-ABCB11 基因座处的效应转录本

Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A Rivas, Heather M Highland, Adam E Locke, Niels Grarup, Hae Kyung Im, Pablo Cingolani, Jason Flannick, Pierre Fontanillas, Christian Fuchsberger, Kyle J Gaulton, Tanya M Teslovich, N William Rayner, Neil R Robertson, Nicola L Beer, Jana

Combining microarray-based genomic selection (MGS) with the Illumina Genome Analyzer platform to sequence diploid target regions

结合基于微阵列的基因组选择(MGS)和Illumina Genome Analyzer平台对二倍体目标区域进行测序

David T Okou,Adam E Locke, Karyn M Steinberg, Katie Hagen, Prashanth Athri, Amol C Shetty, Viren Patel, Michael E Zwick