日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expanding the ligandable proteome by paralog hopping with covalent probes

利用共价探针进行同源物跳跃,扩展可配体蛋白质组

Yuanjin Zhang, Zhonglin Liu, Marsha Hirschi, Oleg Brodsky, Eric Johnson, Sang Joon Won, Asako Nagata, Matthew D Petroski, Jaimeen D Majmudar, Sherry Niessen, Todd VanArsdale, Adam M Gilbert, Matthew M Hayward, Al E Stewart, Andrew R Nager, Bruno Melillo, Benjamin Cravatt

The illusion of moral decline

道德衰落的错觉

Mastroianni, Adam M; Gilbert, Daniel T

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans

设计一种 Janus 激酶 3 (JAK3) 特异性抑制剂 1-((2S,5R)-5-((7H-吡咯并[2,3-d]嘧啶-4-基)氨基)-2-甲基哌啶-1-基)丙-2-烯-1-酮 (PF-06651600),用于检测人类的 JAK3 信号

Atli Thorarensen, Martin E Dowty, Mary Ellen Banker, Brian Juba, Jason Jussif, Tsung Lin, Fabien Vincent, Robert M Czerwinski, Agustin Casimiro-Garcia, Ray Unwalla, John I Trujillo, Sidney Liang, Paul Balbo, Ye Che, Adam M Gilbert, Matthew F Brown, Matthew Hayward, Justin Montgomery, Louis Leung, Xi

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

评估共价激酶抑制剂蛋白质组选择性的路线图

Bryan R Lanning #, Landon R Whitby #, Melissa M Dix, John Douhan, Adam M Gilbert, Erik C Hett, Theodore O Johnson, Chris Joslyn, John C Kath, Sherry Niessen, Lee R Roberts, Mark E Schnute, Chu Wang, Jonathan J Hulce, Baoxian Wei, Laurence O Whiteley, Matthew M Hayward, Benjamin F Cravatt

Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growth via activation of an Akt pathway in neurons

从天然产物筛选中鉴定出的两性霉素 B 可拮抗中枢神经系统抑制剂,通过激活神经元中的 Akt 通路来促进轴突生长

Ying Gao, Kangwen Deng, Zixuan Cao, Edmund I Graziani, Adam M Gilbert, Frank E Koehn, Andrew Wood, Patrick Doherty, Frank S Walsh

(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate

(1-(4-(萘-2-基)嘧啶-2-基)哌啶-4-基)甲胺:一种无翼β-连环蛋白激动剂,可提高骨形成率

Jeffrey C Pelletier, Joseph T Lundquist 4th, Adam M Gilbert, Nipa Alon, Frederick J Bex, Bheem M Bhat, Mattew G Bursavich, Valerie E Coleburn, Luciana A Felix, Daniel M Green, Paula Green, Diane B Hauze, Yogendra P Kharode, Ho-Sun Lam, Susan R Lockhead, Ronald L Magolda, Jeanne J Matteo, John F Mehl