日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3

细胞结合双特异性抗体抗 GUCY2CxCD3 对 GUCY2C 识别的分子见解

Pragya Rampuria #, Lidia Mosyak #, Adam R Root, Kristine Svenson, Michael J Agostino, Edward R LaVallie

Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors

发现和优化用于治疗实体肿瘤的新型抗 GUCY2c x CD3 双特异性抗体

Adam R Root, Gurkan Guntas, Madan Katragadda, James R Apgar, Jatin Narula, Chew Shun Chang, Sara Hanscom, Matthew McKenna, Jason Wade, Caryl Meade, Weijun Ma, Yongjing Guo, Yan Liu, Weili Duan, Claire Hendershot, Amy C King, Yan Zhang, Eric Sousa, Amy Tam, Susan Benard, Han Yang, Kerry Kelleher, Fan

A CD3-bispecific molecule targeting P-cadherin demonstrates T cell-mediated regression of established solid tumors in mice

针对 P-钙粘蛋白的 CD3 双特异性分子证实 T 细胞介导小鼠已建立实体肿瘤的消退

Timothy S Fisher, Andrea T Hooper, Justin Lucas, Tracey H Clark, Allison K Rohner, Bryan Peano, Mark W Elliott, Konstantinos Tsaparikos, Hui Wang, Jonathan Golas, Maria Gavriil, Nahor Haddish-Berhane, Lioudmila Tchistiakova, Hans-Peter Gerber, Adam R Root, Chad May

Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer

开发 PF-06671008,一种具有延长半衰期的高效抗 P-钙粘蛋白/抗 CD3 双特异性 DART 分子,用于治疗癌症

Adam R Root, Wei Cao, Bilian Li, Peter LaPan, Caryl Meade, Jocelyn Sanford, Macy Jin, Cliona O'Sullivan, Emma Cummins, Matthew Lambert, Alfredo D Sheehan, Weijun Ma, Scott Gatto, Kelvin Kerns, Khetemenee Lam, Aaron M D'Antona, Lily Zhu, William A Brady, Susan Benard, Amy King, Tao He, Lisa Racie, Ma