日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preclinical Evaluation of 89Zr-Df-IAB22M2C PET as an Imaging Biomarker for the Development of the GUCY2C-CD3 Bispecific PF-07062119 as a T Cell Engaging Therapy

89Zr-Df-IAB22M2C PET 作为 GUCY2C-CD3 双特异性 PF-07062119 开发为 T 细胞接合疗法的影像生物标记物的临床前评估

Kevin P Maresca, Jianqing Chen, Divya Mathur, Anand Giddabasappa, Adam Root, Jatin Narula, Lindsay King, David Schaer, Jonathan Golas, Keith Kobylarz, Edward Rosfjord, Edmund Keliher, Laigao Chen, Sripad Ram, Eve H Pickering, James S Hardwick, Paul A Rejto, Amira Hussein, Ohad Ilovich, Kevin Staton,

Molecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model

分子成像揭示小鼠异种移植模型中 P-钙粘蛋白 LP-DART 双特异性抗体的生物分布和过继转移 T 细胞的运输

Vijay R Gupta, Adam Root, Timothy Fisher, Rand Norberg, John David, Tracey Clark, Justin Cohen, Chad May, Anand Giddabasappa

A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®

CD3 双特异性分子的转化定量系统药理学模型:用于量化 P-Cadherin LP DART® 对 T 细胞介导的肿瘤细胞杀伤作用

Alison Betts, Nahor Haddish-Berhane, Dhaval K Shah, Piet H van der Graaf, Frank Barletta, Lindsay King, Tracey Clark, Cris Kamperschroer, Adam Root, Andrea Hooper, Xiaoying Chen1