日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tetravalent antibodies are more potent and efficacious erythropoiesis-stimulating agents than erythropoietin in vivo.

四价抗体在体内比促红细胞生成素更有效、更强效的促红细胞生成剂。

Adams Jarrett J, Blazer Levi L, Chung Jacky, Karimi Minoo, Davidson Taylor, Blair Bailey, Waddle Carlos, Hokanson Craig A, Bruce Heather A, Singer Alexander U, Tombak Eva-Maria, Gildemann Kiira, Tamberg Nele, Kiiver Kaja, Ustav Mart Jr, Ma Yue, Colombo Luigi, Huang Lily Jun-Shen, Michnick Stephen W, Moe Orson W, Sidhu Sachdev S

Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation.

靶向 EphA2 的合成抗体可诱导具有不同激活方式的多种信号传导活性簇

Adams Jarrett J, Bruce Heather A, Subramania Suryasree, Ploder Lynda, Garcia Julia, Pot Isabelle, Blazer Levi L, Singer Alexander U, Sidhu Sachdev S

An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor in vitro and in vivo.

不对称四抗体是体外和体内促红细胞生成素受体的强效激动剂

Adams Jarrett J, Blazer Levi L, Chung Jacky, Karimi Minoo, Davidson Taylor, Bruce Heather A, Singer Alexander U, Yang Ning, Cardarelli Lia, Pot Isabelle, Colombo Luigi, Huang Lily Jun-Shen, Ma Yue, Michnick Stephen W, Moe Orson W, Sidhu Sachdev S

Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones

具有改进的晶格堆积和增强的肘部构象灵活性的抗原结合片段作为结晶伴侣

Bruce, Heather A; Singer, Alexander U; Blazer, Levi L; Luu, Khanh; Ploder, Lynda; Pavlenco, Alevtina; Kurinov, Igor; Adams, Jarrett J; Sidhu, Sachdev S

A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties

一种经过基因工程改造、具有更广泛特异性的合成抗Frizzled抗体表现出增强的抗肿瘤特性

Pavlovic, Zvezdan; Adams, Jarrett J; Blazer, Levi L; Gakhal, Amandeep K; Jarvik, Nick; Steinhart, Zachary; Robitaille, Mélanie; Mascall, Keith; Pan, James; Angers, Stephane; Moffat, Jason; Sidhu, Sachdev S

Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity

生殖系相互作用与适应性识别之间的结构性相互作用决定了TCR-肽-MHC交叉反应的带宽

Adams, Jarrett J; Narayanan, Samanthi; Birnbaum, Michael E; Sidhu, Sachdev S; Blevins, Sydney J; Gee, Marvin H; Sibener, Leah V; Baker, Brian M; Kranz, David M; Garcia, K Christopher

CDR-H3 diversity is not required for antigen recognition by synthetic antibodies

合成抗体识别抗原并不需要CDR-H3多样性

Persson, Helena; Ye, Wei; Wernimont, Amy; Adams, Jarrett J; Koide, Akiko; Koide, Shohei; Lam, Robert; Sidhu, Sachdev S

Scaffoldin conformation and dynamics revealed by a ternary complex from the Clostridium thermocellum cellulosome

通过来自嗜热梭菌纤维素体的三元复合物揭示支架蛋白的构象和动力学

Currie, Mark A; Adams, Jarrett J; Faucher, Frédérick; Bayer, Edward A; Jia, Zongchao; Smith, Steven P

T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex

T细胞受体信号传导受限于其与肽-主要组织相容性复合物的对接几何结构。

Adams, Jarrett J; Narayanan, Samanthi; Liu, Baoyu; Birnbaum, Michael E; Kruse, Andrew C; Bowerman, Natalie A; Chen, Wei; Levin, Aron M; Connolly, Janet M; Zhu, Cheng; Kranz, David M; Garcia, K Christopher

Purification and crystallization of a multimodular heterotrimeric complex containing both type I and type II cohesin-dockerin interactions from the cellulosome of Clostridium thermocellum

从嗜热梭菌的纤维素体中纯化和结晶含有I型和II型内聚素-对接蛋白相互作用的多模块异源三聚体复合物

Currie, Mark A; Adams, Jarrett J; Ali, Sabrina; Smith, Steven P; Jia, Zongchao