日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

PPARα-NF-κB heterodimer mediates obesity-induced diastolic dysfunction through autocrine production of IL-6

PPARα-NF-κB异二聚体通过自分泌产生IL-6介导肥胖诱导的舒张功能障碍

期刊:Journal of Clinical Investigation
影响因子:
doi:10.1172/JCI196238
Oka, Shin-Ichi; Sung, Eun-Ah; Zhai, Peiyong; Schesing, Kevin B; Bhat, Santosh; Chin, Adave; Park, Jiyeon; Chung, Yeun-Jun; Shirakabe, Akihiro; Yamamoto, Takanobu; Ikeda, Yoshiyuki; Mizushima, Wataru; Ikeda, Shohei; Tong, Mingming; Byun, Jaemin; Nakamura, Michinari; Kim, Samuel I; Francisco, Jamie; Del Re, Dominic P; Sadoshima, Junichi
NF-κB
肥胖
IL-6
代谢
发表日期：2026
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β-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes

β-羟基丁酸是一种酮体，可通过上调心肌细胞中的硫氧还蛋白 1 来增强抗氧化防御能力

期刊:Antioxidants
影响因子:
doi:10.3390/antiox10071153
Shin-Ichi Oka, Fan Tang, Adave Chin, Guersom Ralda, Xiaoyong Xu, Chengchen Hu, Zhi Yang, Maha Abdellatif, Junichi Sadoshima
细胞生物学
其它细胞
WB
NMNAT1
发表日期：2021
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Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1α (Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α) Dysregulation

衰竭心脏中RNA聚合酶II向代谢基因启动子的募集受到抑制，这可能是通过PGC-1α（过氧化物酶体增殖物激活受体γ共激活因子-1α）失调实现的。

期刊:Circulation-Heart Failure
影响因子:8.4
doi:10.1161/CIRCHEARTFAILURE.118.005529
Bhat, Santosh; Chin, Adave; Shirakabe, Akihiro; Ikeda, Yoshiyuki; Ikeda, Shohei; Zhai, Peiyong; Hsu, Chiao-Po; Sayed, Danish; Abdellatif, Maha; Byun, Jaemin; Schesing, Kevin; Tang, Fan; Tian, Yimin; Babu, Gopal; Ralda, Guersom; Warren, Junco S; Cho, Jaeyeaon; Sadoshima, Junichi; Oka, Shin-Ichi
信号转导
代谢
发表日期：2019
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Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction

过氧化物酶体增殖激活受体α/γ双重激活抑制SIRT1-PGC1α轴并导致心脏功能障碍

期刊:JCI Insight
影响因子:6.3
doi:10.1172/jci.insight.129556
Charikleia Kalliora, Ioannis D Kyriazis, Shin-Ichi Oka, Melissa J Lieu, Yujia Yue, Estela Area-Gomez, Christine J Pol, Ying Tian, Wataru Mizushima, Adave Chin, Diego Scerbo, P Christian Schulze, Mete Civelek, Junichi Sadoshima, Muniswamy Madesh, Ira J Goldberg, Konstantinos Drosatos
信号转导
发表日期：2019
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Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes

硫氧还蛋白-1 在心肌细胞氧化应激期间维持雷帕霉素 (mTOR) 的机制靶点功能

期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.M117.807735
Shin-Ichi Oka, Tsuyoshi Hirata, Wataru Suzuki, Daichi Naito, Yanbin Chen, Adave Chin, Hiroaki Yaginuma, Toshiro Saito, Narayani Nagarajan, Peiyong Zhai, Santosh Bhat, Kevin Schesing, Dan Shao, Yoko Hirabayashi, Junji Yodoi, Sebastiano Sciarretta, Junichi Sadoshima
信号转导
其它细胞
mTOR
发表日期：2017
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