Discovery of Dual BCL-xL/BCL-w Degraders by Exploiting the Bis(sulfonyl)benzene Ring of ABT-263 as a Linkage Vector
利用ABT-263的双(磺酰基)苯环作为连接载体,发现双重BCL-xL/BCL-w降解剂
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01834
Poddar, Saikat K; Yang, Yang; Pal, Pratik; Jin, Zeng; Pei, Jing; Xiao, Yufeng; Hu, Wanyi; Zhang, Peiyi; Adekunbi, Praise; Thummuri, Dinesh; Yuan, Yaxia; Lv, Dongwen; Pelletier, J Peter R; Zhang, Weizhou; Zhou, Daohong; Zheng, Guangrong