日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs

具有广谱抗疟原虫活性并与抗疟药物有协同作用的新型腙化合物

Angélica M Rosado-Quiñones, Emilee E Colón-Lorenzo, Zarna Rajeshkumar Pala, Jürgen Bosch, Karl Kudyba, Heather Kudyba, Susan E Leed, Norma Roncal, Abel Baerga-Ortiz, Abiel Roche-Lima, Yamil Gerena, David A Fidock, Alison Roth, Joel Vega-Rodríguez #, Adelfa E Serrano #

Antimalarial Drug Combination Predictions Using the Machine Learning Synergy Predictor (MLSyPred©) tool

利用机器学习协同预测器 (MLSyPred©) 工具进行抗疟疾药物组合预测

Roche-Lima, Abiel; Rosado-Quiñones, Angélica M; Feliu-Maldonado, Roberto A; Figueroa-Gispert, María Del Mar; Díaz-Rivera, Jennifer; Díaz-González, Roberto G; Carrasquillo-Carrion, Kelvin; Nieves, Brenda G; Colón-Lorenzo, Emilee E; Serrano, Adelfa E

Probing the Antiplasmodial Properties of Plakortinic Acids C and D: An Uncommon Pair of Marine Peroxide-Polyketides Isolated from a Two-Sponge Association of Plakortis symbiotica and Xetospongia deweerdtae Collected near Puerto Rico

探究 Plakortinic 酸 C 和 D 的抗疟原虫特性:从波多黎各附近收集的 Plakortis symbiotica 和 Xetospongia deweerdtae 双海绵共生体中分离出的一对不常见的海洋过氧化物-聚酮化合物

Luis A Amador, Emilee E Colón-Lorenzo, Abimael D Rodríguez, Adelfa E Serrano

Two Gracilioethers Containing a [2(5H)-Furanylidene]ethanoate Moiety and 9,10-Dihydroplakortone G: New Polyketides from the Caribbean Marine Sponge Plakortis halichondrioides

两种含有[2(5H)-呋喃亚甲基]乙酸酯部分的纤细醚和9,10-二氢plakortone G:来自加勒比海海洋海绵Plakortis halichondrioides的新型聚酮化合物

Amador, Luis A; Rodríguez, Abimael D; Carmona-Sarabia, Lesly; Colón-Lorenzo, Emilee E; Serrano, Adelfa E

Structure-Based Screening of Plasmodium berghei Glutathione S-Transferase Identifies CB-27 as a Novel Antiplasmodial Compound

基于伯氏疟原虫谷胱甘肽 S 转移酶的结构筛选鉴定出 CB-27 是一种新型抗疟原虫化合物

Emilee E Colón-Lorenzo, Daisy D Colón-López, Joel Vega-Rodríguez, Alice Dupin, David A Fidock, Abel Baerga-Ortiz, José G Ortiz, Jürgen Bosch, Adelfa E Serrano

Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage

缺乏谷胱甘肽的伯氏疟原虫表现出生长迟缓和核DNA损伤。

Padín-Irizarry, Vivian; Colón-Lorenzo, Emilee E; Vega-Rodríguez, Joel; Castro, María Del R; González-Méndez, Ricardo; Ayala-Peña, Sylvette; Serrano, Adelfa E

Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites

多药ATP结合盒转运蛋白对于疟原虫子孢子的肝脏发育至关重要。

Sanna R Rijpma,Maarten van der Velden,Maria González-Pons,Takeshi Annoura,Ben C L van Schaijk,Geert-Jan van Gemert,Jeroen J M W van den Heuvel,Jai Ramesar,Severine Chevalley-Maurel,Ivo H Ploemen,Shahid M Khan,Jean-Francois Franetich,Dominique Mazier,Johannes H W de Wilt,Adelfa E Serrano,Frans G M Russel,Chris J Janse,Robert W Sauerwein,Jan B Koenderink,Blandine M Franke-Fayard

Implications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and Artemisinin

谷胱甘肽水平对伯氏疟原虫氯喹和青蒿素反应的影响

Vega-Rodríguez, Joel; Pastrana-Mena, Rebecca; Crespo-Lladó, Keila N; Ortiz, José G; Ferrer-Rodríguez, Iván; Serrano, Adelfa E

Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents

以多样性为导向的合成促进药物化学:迈向新型抗疟药物的开发

Comer, Eamon; Beaudoin, Jennifer A; Kato, Nobutaka; Fitzgerald, Mark E; Heidebrecht, Richard W; Lee, Maurice duPont 4th; Masi, Daniela; Mercier, Marion; Mulrooney, Carol; Muncipinto, Giovanni; Rowley, Ann; Crespo-Llado, Keila; Serrano, Adelfa E; Lukens, Amanda K; Wiegand, Roger C; Wirth, Dyann F; Palmer, Michelle A; Foley, Michael A; Munoz, Benito; Scherer, Christina A; Duvall, Jeremy R; Schreiber, Stuart L

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors

四环苯并噻嗪类药物作为恶性疟原虫细胞色素 bc1 抑制剂的鉴定和验证

Carolyn K Dong, Sameer Urgaonkar, Joseph F Cortese, Francisco-Javier Gamo, Jose F Garcia-Bustos, Maria J Lafuente, Vishal Patel, Leila Ross, Bradley I Coleman, Emily R Derbyshire, Clary B Clish, Adelfa E Serrano, Mandy Cromwell, Robert H Barker Jr, Jeffrey D Dvorin, Manoj T Duraisingh, Dyann F Wirth