日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ART-free HIV-1 remission in children with in-utero HIV-1 after very early ART (IMPAACT P1115): a multicentre, open-label, phase 1/2 proof-of-concept study

早期接受抗逆转录病毒疗法(ART)后,宫内感染HIV-1的儿童可实现无ART治疗的HIV-1缓解(IMPAACT P1115):一项多中心、开放标签、1/2期概念验证研究

Persaud, Deborah; Coletti, Anne; Nelson, Bryan S; Jao, Jennifer; Capparelli, Edmund V; Costello, Diane; Tierney, Camlin; Kekitiinwa, Adeodata R; Nematadzira, Teacler; Njau, Boniface N; Moye, John; Jean-Philippe, Patrick; Korutaro, Violet; Nalugo, Annet; Mbengeranwa, Tapiwa; Chidemo, Tinashe; Mmbaga, Blandina T; Sakasaka, Philoteus A; Cotton, Mark; Jennings, Cheryl; Hoffmann, Carly; Hovind, Laura; Bryson, Yvonne; Chadwick, Ellen G

BREATHER Plus clinical trial design: A randomised non-inferiority trial evaluating the efficacy, safety and acceptability of short cycle (five days on, two days off) dolutegravir/tenofovir-based triple antiretroviral therapy (ART) compared to daily ART in virologically suppressed adolescents living with HIV aged 12 to <20 years in sub-Saharan Africa

BREATHER Plus 临床试验设计:一项随机非劣效性试验,旨在评估短周期(用药五天,停药两天)基于多替拉韦/替诺福韦的三联抗逆转录病毒疗法 (ART) 与每日 ART 相比,在撒哈拉以南非洲地区 12 至 20 岁以下 HIV 感染青少年中,病毒学抑制的疗效、安全性和可接受性。

Katongole, Fredrick; Arumugam, Tiyara; Jennings, Angus; Mutata, Constantine; Ssebunya, Patrick; Wamboi, Charity; Green, Alexandra; Bwakura-Dangarembizi, Mutsa; Kityo, Cissy; Siika, Abraham; Archary, Moherndran; Jafta, Lungile; Namukwaya, Stella; Seeley, Janet; Mugerwa, Henry; Walker, Simon; Apoto, Naomi; Thomason, Margaret J; Ford, Deborah; Pett, Sarah L; Kekitiinwa, Adeodata R

The time is now to use the tools we have to end AIDS in children

现在是时候利用我们现有的工具来终结儿童艾滋病了。

Vojnov, Lara; Shapiro, Roger L; Mulenga, Lloyd B; Kikitiinwa, Adeodata R; Vrazo, Alexandra C; Ekouévi, Patricia Fassinou; Dindi, Nelly Pato; Tiam, Appolinaire; Persaud, Deborah; Mofenson, Lynne

HIV-1 reservoir size after neonatal antiretroviral therapy and the potential to evaluate antiretroviral-therapy-free remission (IMPAACT P1115): a phase 1/2 proof-of-concept study

新生儿抗逆转录病毒治疗后HIV-1病毒库大小及评估无需抗逆转录病毒治疗即可缓解的可能性(IMPAACT P1115):一项1/2期概念验证研究

Persaud, Deborah; Bryson, Yvonne; Nelson, Bryan S; Tierney, Camlin; Cotton, Mark F; Coletti, Anne; Jao, Jennifer; Spector, Stephen A; Mirochnick, Mark; Capparelli, Edmund V; Costello, Diane; Szewczyk, Joseph; Nicodimus, Nicol; Stranix-Chibanda, Lynda; Kekitiinwa, Adeodata R; Korutaro, Violet; Reding, Christina; Carrington, Mary N; Majji, Sai; Yin, Dwight E; Jean-Philippe, Patrick; Chadwick, Ellen G

D3/Penta 21 clinical trial design: A randomised non-inferiority trial with nested drug licensing substudy to assess dolutegravir and lamivudine fixed dose formulations for the maintenance of virological suppression in children with HIV-1 infection, aged 2 to 15 years

D3/Penta 21 临床试验设计:一项随机非劣效性试验,包含嵌套的药物许可子研究,旨在评估多替拉韦和拉米夫定固定剂量制剂在维持 2 至 15 岁 HIV-1 感染儿童病毒学抑制方面的疗效。

Turkova, Anna; Chan, Man K; Kityo, Cissy; Kekitiinwa, Adeodata R; Musoke, Philippa; Violari, Avy; Variava, Ebrahim; Archary, Moherndran; Cressey, Tim R; Chalermpantmetagul, Suwalai; Sawasdichai, Kanokkorn; Ounchanum, Pradthana; Kanjanavanit, Suparat; Srirojana, Sakulrat; Srirompotong, Ussanee; Welch, Steven; Bamford, Alasdair; Epalza, Cristina; Fortuny, Clàudia; Colbers, Angela; Nastouli, Eleni; Walker, Simon; Carr, Dan; Conway, Magda; Spyer, Moira J; Parkar, Nazia; White, Iona; Nardone, Alessandra; Thomason, Margaret J; Ferrand, Rashida A; Giaquinto, Carlo; Ford, Deborah

Nucleoside/nucleotide reverse transcriptase inhibitor sparing regimen with once daily integrase inhibitor plus boosted darunavir is non-inferior to standard of care in virologically-suppressed children and adolescents living with HIV - Week 48 results of the randomised SMILE Penta-17-ANRS 152 clinical trial

在病毒学抑制的 HIV 感染儿童和青少年中,每日一次整合酶抑制剂联合达芦那韦增强治疗方案(无需使用核苷/核苷酸类逆转录酶抑制剂)不劣于标准治疗方案——随机 SMILE Penta-17-ANRS 152 临床试验第 48 周结果

Compagnucci, Alexandra; Chan, Man K; Saïdi, Yacine; Cressey, Tim R; Bamford, Alasdair; Riault, Yoann; Coelho, Alexandra; Nolan, Aoife; Chalermpantmetagul, Suwalai; Morkunaite, Gabija; Amuge, Pauline; Musiime, Victor; Violari, Avy; Cotton, Mark; Kekitiinwa, Adeodata R; Kaudha, Elizabeth; Groenewald, Marisa; Liberty, Afaaf A; Kanjanavanit, Suparat; Volokha, Alla; Bologna, Rosa; Pavia Ruz, Noris; Prieto Tato, Luis; Paioni, Paolo; Marques, Laura; Reliquet, Véronique; Niehues, Tim; Welch, Steven B; Ford, Deborah; Giaquinto, Carlo; Gibb, Diana M; Babiker, Abdel; Ramos Amador, Jose Tomas

Effect of dolutegravir on folate, vitamin B12 and mean corpuscular volume levels among children and adolescents with HIV: a sub-study of the ODYSSEY randomized controlled trial

多替拉韦对 HIV 感染儿童和青少年叶酸、维生素 B12 和平均红细胞体积水平的影响:ODYSSEY 随机对照试验的子研究

Barlow-Mosha, Linda Namutebi; Ahimbisibwe, Grace Miriam; Chappell, Elizabeth; Amuge, Pauline Mary; Nanduudu, Annet; Kaudha, Elizabeth; Amukele, Timothy; Balamusani, David; Kafufu, Bosco; Nimwesiga, Audrey; Kataike, Hajira; Namwanje, Rosemary; Kasangaki, Gladys; Mulindwa, Alice; Muzorah, Gerald Agaba; Bbuye, Dickson; Musiime, Victor; Mujyambere, Emmanuel; Ssenyonga, Mark; Mulima, Disan; Kyambadde, Raymonds Crespo; Namusanje, Josephine; Isabirye, Richard; Nabalamba, Mariam; Nakirya, Barbara Musoke; Kityo, Cissy; Kekitiinwa, Adeodata R; Giaquinto, Carlo; Copp, Andrew; Gibb, Diana M; Ford, Deborah; Musoke, Philippa; Turkova, Anna

Dolutegravir dosing for children with HIV weighing less than 20 kg: pharmacokinetic and safety substudies nested in the open-label, multicentre, randomised, non-inferiority ODYSSEY trial

多替拉韦用于体重低于 20 公斤的 HIV 感染儿童的给药方案:嵌套于开放标签、多中心、随机、非劣效性 ODYSSEY 试验中的药代动力学和安全性子研究

Waalewijn, Hylke; Chan, Man K; Bollen, Pauline D J; Mujuru, Hilda A; Makumbi, Shafic; Kekitiinwa, Adeodata R; Kaudha, Elizabeth; Sarfati, Tatiana; Musoro, Godfrey; Nanduudu, Annet; Lugemwa, Abbas; Amuge, Pauline; Moore, Cecilia L; Rojo, Pablo; Giaquinto, Carlo; Colbers, Angela; Gibb, Diana M; Ford, Deborah; Turkova, Anna; Burger, David M

Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial

在HIV相关结核病患儿中,每日两次服用多替拉韦的药代动力学和安全性研究:一项开放标签、多中心、随机、非劣效性ODYSSEY试验

Turkova, Anna; Waalewijn, Hylke; Chan, Man K; Bollen, Pauline D J; Bwakura-Dangarembizi, Mutsa F; Kekitiinwa, Adeodata R; Cotton, Mark F; Lugemwa, Abbas; Variava, Ebrahim; Ahimbisibwe, Grace Miriam; Srirompotong, Ussanee; Mumbiro, Vivian; Amuge, Pauline; Zuidewind, Peter; Ali, Shabinah; Kityo, Cissy M; Archary, Moherndran; Ferrand, Rashida A; Violari, Avy; Gibb, Diana M; Burger, David M; Ford, Deborah; Colbers, Angela

Once-daily dolutegravir-based antiretroviral therapy in infants and children living with HIV from age 4 weeks: results from the below 14 kg cohort in the randomised ODYSSEY trial

对4周龄及以上感染HIV的婴幼儿进行每日一次基于多替拉韦的抗逆转录病毒疗法:来自随机ODYSSEY试验中体重低于14公斤队列的结果

Amuge, Pauline; Lugemwa, Abbas; Wynne, Ben; Mujuru, Hilda A; Violari, Avy; Kityo, Cissy M; Archary, Moherndran; Variava, Ebrahim; White, Ellen; Turner, Rebecca M; Shakeshaft, Clare; Ali, Shabinah; Nathoo, Kusum J; Atwine, Lorna; Liberty, Afaaf; Bbuye, Dickson; Kaudha, Elizabeth; Mngqibisa, Rosie; Mosala, Modehei; Mumbiro, Vivian; Nanduudu, Annet; Ankunda, Rogers; Maseko, Lindiwe; Kekitiinwa, Adeodata R; Giaquinto, Carlo; Rojo, Pablo; Gibb, Diana M; Turkova, Anna; Ford, Deborah