日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Decay of driver mutations shapes the landscape of intestinal transformation.

驱动基因突变的衰减塑造了肠道转化的格局。

Lourenço Filipe C, Sadien Iannish D, Wong Kim, Adler Sam, Sawle Ashley, Santana Leonor Schubert, Hazelwood Lee, Giavara Giada, Nicholson Anna M, Eldridge Matthew D, Maka Noori, Lynch Gerard, McSorley Stephen T, Edwards Joanne, Kemp Richard, Adams David J, Winton Douglas J

Haploinsufficient phenotypes promote selection of PTEN and ARID1A-deficient clones in human colon.

单倍体不足表型促进人类结肠中 PTEN 和 ARID1A 缺陷克隆的选择

Skoufou-Papoutsaki Nefeli, Adler Sam, Mehmed Shenay, Tume Claire, Olpe Cora, Morrissey Edward, Kemp Richard, Girard Anne-Claire, Moutin Elisa B, Chilamakuri Chandra Sekhar Reddy, Miller Jodi L, Lindskog Cecilia, Werle Fabian, Marks Kate, Perrone Francesca, Zilbauer Matthias, Tourigny David S, Winton Douglas J

Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn's Disease

患者来源的类器官生物库发现,肠上皮MHC-I的表观遗传失调是重症克罗恩病的一种新机制

Dennison, Thomas W; Edgar, Rachel D; Payne, Felicity; Nayak, Komal M; Ross, Alexander D B; Cenier, Aurelie; Glemas, Claire; Giachero, Federica; Foster, April R; Harris, Rebecca; Kraiczy, Judith; Salvestrini, Camilla; Stavrou, Georgia; Torrente, Franco; Brook, Kimberley; Trayers, Claire; Elmentaite, Rasa; Youssef, Gehad; Tél, Bálint; Winton, Douglas James; Skoufou-Papoutsaki, Nefeli; Adler, Sam; Bufler, Philip; Azabdaftari, Aline; Jenke, Andreas; G, Natasha; Thomas, Natasha; Miele, Erasmo; Al-Mohammad, Abdulrahman; Guarda, Greta; Kugathasan, Subra; Venkateswaran, Suresh; Clatworthy, Menna R; Castro-Dopico, Tomas; Suchanek, Ondrej; Strisciuglio, Caterina; Gasparetto, Marco; Lee, Seokjun; Xu, Xingze; Bello, Erica; Han, Namshik; Zerbino, Daniel R; Teichmann, Sarah A; Nys, Josquin; Heuschkel, Robert; Perrone, Francesca; Zilbauer, Matthias