日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-Based Discovery of Obeticholic Acid Derivatives as Novel Farnesoid X Receptor Partial Agonists with Improved Selectivity and Reduced Off-Target Effects

基于结构的奥贝胆酸衍生物作为新型法尼醇X受体部分激动剂的发现,具有更高的选择性和更低的脱靶效应

Passeri, Daniela; Cerra, Bruno; Carotti, Andrea; Greco, Francesco; Piermarini, Sara; Colliva, Carolina; Liscio, Paride; De Franco, Francesca; Adorini, Luciano; Erickson, Mary Ruth; Pellicciari, Roberto; Gioiello, Antimo

Farnesoid X Receptor Agonist INT-787 Inhibits Hepatic Mitochondrial Dysfunction in a Diet-Induced ob/ob Mouse Model of MASH

法尼醇X受体激动剂INT-787可抑制饮食诱导的ob/ob小鼠MASH模型中的肝线粒体功能障碍。

Di Pasqua, Laura Giuseppina; Palladini, Giuseppina; Croce, Anna Cleta; Milanesi, Gloria; Cavallo, Margherita; Adorini, Luciano; Ferrigno, Andrea; Vairetti, Mariapia

Aberrant basement membrane production by HSCs in MASLD is attenuated by the bile acid analog INT-767

胆汁酸类似物 INT-767 可减弱 MASLD 中 HSC 产生的异常基底膜

Prakash Ramachandran, Madara Brice, Elena F Sutherland, Anna M Hoy, Eleni Papachristoforou, Li Jia, Frances Turner, Timothy J Kendall, John A Marwick, Neil O Carragher, Denise Oro, Michael Feigh, Diana J Leeming, Mette J Nielsen, Morten A Karsdal, Nadine Hartmann, Mary Erickson, Luciano Adorini, Jon

Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticholic acid in a mouse model of nonalcoholic steatohepatitis

在非酒精性脂肪性肝炎小鼠模型中,新型法尼醇X受体激动剂INT-787的保肝作用优于奥贝胆酸。

Luciano Adorini ,Kristoffer Rigbolt ,Michael Feigh ,Jonathan Roth ,Mary Erickson

Protective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling

UDCA 对 IL-11 诱导的心脏纤维化的保护作用由 TGR5 信号传导介导

B Reilly-O'Donnell, E Ferraro, R Tikhomirov, R Nunez-Toldra, A Shchendrygina, L Patel, Y Wu, A L Mitchell, A Endo, L Adorini, R A Chowdhury, P K Srivastava, F S Ng, C Terracciano, C Williamson, J Gorelik

An integrated analysis of fecal microbiome and metabolomic features distinguish non-cirrhotic NASH from healthy control populations

粪便微生物组和代谢组特征的综合分析能够区分非肝硬化性NASH患者和健康对照人群。

Carr, Rotonya M; Li, Yun; Chau, Lillian; Friedman, Elliot S; Lee, Jung-Jin; Adorini, Luciano; Erickson, Mary; Zaru, Luna; Shringarpure, Reshma; MacConell, Leigh; Bittinger, Kyle; Li, Hongzhe; Wu, Gary D

Altered ethanol metabolism and increased oxidative stress enhance alcohol-associated liver injury in farnesoid X receptor-deficient mice

乙醇代谢改变和氧化应激增加会增强法呢醇 X 受体缺陷小鼠的酒精相关肝损伤

Caroline Morel, Vivek Chowdhary, Prashanth Thevkar Nagesh, Marcelle Ribeiro, Danielle Hawryluk, Donna Catalano, Luciano Adorini, Gyongyi Szabo

Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2

法尼醇X受体增强上皮细胞ACE2表达并抑制病毒诱导的IL-6分泌:对SARS-CoV-2肠道症状的意义

Smyth, Jessica S; Truong, Jennifer K; Rao, Anuradha; Lin, Ruxian; Foulke-Abel, Jennifer; Adorini, Luciano; Donowitz, Mark; Dawson, Paul A; Keely, Stephen J

Enterohepatic Takeda G-Protein Coupled Receptor 5 Agonism in Metabolic Dysfunction-Associated Fatty Liver Disease and Related Glucose Dysmetabolism

肠肝武田 G 蛋白偶联受体 5 激动剂在代谢功能障碍相关脂肪肝疾病和相关葡萄糖代谢异常中的作用

Justine Gillard, Corinne Picalausa, Christoph Ullmer, Luciano Adorini, Bart Staels, Anne Tailleux, Isabelle A Leclercq

The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice

FXR 和 TGR5 在逆转和预防小鼠西方饮食引起的肝脂肪变性、炎症和纤维化进展中的作用

Xiaoxin X Wang, Cen Xie, Andrew E Libby, Suman Ranjit, Jonathan Levi, Komuraiah Myakala, Kanchan Bhasin, Bryce A Jones, David J Orlicky, Shogo Takahashi, Alexander Dvornikov, David E Kleiner, Stephen M Hewitt, Luciano Adorini, Jeffrey B Kopp, Kristopher W Krausz, Avi Rosenberg, James L McManaman, Ch