日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Structure-Based Discovery of Obeticholic Acid Derivatives as Novel Farnesoid X Receptor Partial Agonists with Improved Selectivity and Reduced Off-Target Effects

基于结构的奥贝胆酸衍生物作为新型法尼醇X受体部分激动剂的发现，具有更高的选择性和更低的脱靶效应

期刊:ChemMedChem
影响因子:3.4
doi:10.1002/cmdc.202500960
Passeri, Daniela; Cerra, Bruno; Carotti, Andrea; Greco, Francesco; Piermarini, Sara; Colliva, Carolina; Liscio, Paride; De Franco, Francesca; Adorini, Luciano; Erickson, Mary Ruth; Pellicciari, Roberto; Gioiello, Antimo
信号转导
发表日期：2026
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Farnesoid X Receptor Agonist INT-787 Inhibits Hepatic Mitochondrial Dysfunction in a Diet-Induced ob/ob Mouse Model of MASH

法尼醇X受体激动剂INT-787可抑制饮食诱导的ob/ob小鼠MASH模型中的肝线粒体功能障碍。

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms262211023
Di Pasqua, Laura Giuseppina; Palladini, Giuseppina; Croce, Anna Cleta; Milanesi, Gloria; Cavallo, Margherita; Adorini, Luciano; Ferrigno, Andrea; Vairetti, Mariapia
信号转导
Mouse
线粒体
发表日期：2025
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An integrated analysis of fecal microbiome and metabolomic features distinguish non-cirrhotic NASH from healthy control populations

粪便微生物组和代谢组特征的综合分析能够区分非肝硬化性NASH患者和健康对照人群。

期刊:Hepatology
影响因子:15.8
doi:10.1097/HEP.0000000000000474
Carr, Rotonya M; Li, Yun; Chau, Lillian; Friedman, Elliot S; Lee, Jung-Jin; Adorini, Luciano; Erickson, Mary; Zaru, Luna; Shringarpure, Reshma; MacConell, Leigh; Bittinger, Kyle; Li, Hongzhe; Wu, Gary D
微生物学
肝硬化
代谢
发表日期：2023
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Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2

法尼醇X受体增强上皮细胞ACE2表达并抑制病毒诱导的IL-6分泌：对SARS-CoV-2肠道症状的意义

期刊:American Journal of Physiology-Gastrointestinal and Liver Physiology
影响因子:3.3
doi:10.1152/ajpgi.00099.2023
Smyth, Jessica S; Truong, Jennifer K; Rao, Anuradha; Lin, Ruxian; Foulke-Abel, Jennifer; Adorini, Luciano; Donowitz, Mark; Dawson, Paul A; Keely, Stephen J
SARS-CoV-2
上皮细胞
信号转导
微生物学
细胞生物学
IL-6
ACE2
发表日期：2023
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FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid

胆汁酸衍生物奥贝胆酸通过FXR依赖性途径调节人小肠微生物群

期刊:Gastroenterology
影响因子:25.1
doi:10.1053/j.gastro.2018.08.022
Friedman, Elliot S; Li, Yun; Shen, Ting-Chin David; Jiang, Jack; Chau, Lillian; Adorini, Luciano; Babakhani, Farah; Edwards, Jeffrey; Shapiro, David; Zhao, Chunyu; Carr, Rotonya M; Bittinger, Kyle; Li, Hongzhe; Wu, Gary D
微生物学
Human
发表日期：2018
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A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis

奥贝胆酸单药治疗原发性胆汁性胆管炎患者的随机试验

期刊:Hepatology
影响因子:15.8
doi:10.1002/hep.29569
Kowdley, Kris V; Luketic, Velimir; Chapman, Roger; Hirschfield, Gideon M; Poupon, Raoul; Schramm, Christoph; Vincent, Catherine; Rust, Christian; Parés, Albert; Mason, Andrew; Marschall, Hanns-Ulrich; Shapiro, David; Adorini, Luciano; Sciacca, Cathi; Beecher-Jones, Tessa; Böhm, Olaf; Pencek, Richard; Jones, David
发表日期：2018
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Megatrends in bile acid receptor research

胆汁酸受体研究的总体趋势

期刊:Hepatology Communications
影响因子:4.6
doi:10.1002/hep4.1085
Adorini, Luciano; Schoonjans, Kristina; Friedman, Scott L
信号转导
发表日期：2017
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Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

法尼醇X受体激活可通过调节小鼠胆汁酸组成和胆固醇吸收来增加逆向胆固醇转运。

期刊:Hepatology
影响因子:15.8
doi:10.1002/hep.28712
Xu, Yang; Li, Fei; Zalzala, Munaf; Xu, Jiesi; Gonzalez, Frank J; Adorini, Luciano; Lee, Yoon-Kwang; Yin, Liya; Zhang, Yanqiao
信号转导
代谢
发表日期：2016
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Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis

肝羧酸酯酶1对于正常的脂质稳态和法尼醇X受体控制的脂质稳态都至关重要。

期刊:Hepatology
影响因子:15.8
doi:10.1002/hep.26714
Xu, Jiesi; Li, Yuanyuan; Chen, Wei-Dong; Xu, Yang; Yin, Liya; Ge, Xuemei; Jadhav, Kavita; Adorini, Luciano; Zhang, Yanqiao
信号转导
发表日期：2014
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TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading

TGR5激活通过减少巨噬细胞炎症和脂质沉积来抑制动脉粥样硬化。

期刊:Cell Metabolism
影响因子:30.9
doi:10.1016/j.cmet.2011.11.006
Pols, Thijs W H; Nomura, Mitsunori; Harach, Taoufiq; Lo Sasso, Giuseppe; Oosterveer, Maaike H; Thomas, Charles; Rizzo, Giovanni; Gioiello, Antimo; Adorini, Luciano; Pellicciari, Roberto; Auwerx, Johan; Schoonjans, Kristina
巨噬细胞
炎症
炎症/感染
巨噬细胞
心血管
细胞生物学
动脉粥样硬化
免疫/内分泌
发表日期：2011
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