日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA

反义二肽重复蛋白通过ADA驱动C9orf72肌萎缩侧索硬化症中广泛的嘌呤代谢异常。

Benjamin Hall,Lydia Castelli,Adrian Higginbottom,Jingxuan He,Ling-Nan Zou,Heather Walker,Miriam Yagüe-Capilla,Kari E Wong,David J Burrows,Jonathan George,Keaton Hamer,Jenny M Tanner,Ergita Kyrgiou-Balli,Rees Ross,Herbie Garland,Erin Tonkiss,Rachel George,Christopher P Webster,Emma F Smith,Hannah O Timmons,Jess Allsop,Nikolas Stefanidis,Billie D Ward,Ya-Hui Lin,J Robin Highley,Mimoun Azzouz,Ryan J H West,Sean G Rudd,Kurt J De Vos,Pamela J Shaw,Guillaume M Hautbergue,Scott P Allen

A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests 'space cadet syndrome' on two FVB backgrounds

肌萎缩侧索硬化症的细菌人工染色体小鼠模型在两种 FVB 背景下表现出“太空学员综合征”

Sophie E Badger, Ian Coldicott, Ergita Kyrgiou-Balli, Adrian Higginbottom, Chloé Moutin, Kamallia Mohd Imran, John C Day, Johnathan Cooper-Knock, Richard J Mead, James J P Alix

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease

与载脂蛋白E的共聚集调节淀粉样蛋白β在阿尔茨海默病中的功能

Zengjie Xia # ,Emily E Prescott # ,Agnieszka Urbanek # ,Hollie E Wareing ,Marianne C King ,Anna Olerinyova ,Helen Dakin ,Tom Leah ,Katy A Barnes ,Martyna M Matuszyk ,Eleni Dimou ,Eric Hidari ,Yu P Zhang ,Jeff Y L Lam ,John S H Danial ,Michael R Strickland ,Hong Jiang ,Peter Thornton ,Damian C Crowther ,Sohvi Ohtonen ,Mireia Gómez-Budia ,Simon M Bell ,Laura Ferraiuolo ,Heather Mortiboys ,Adrian Higginbottom ,Stephen B Wharton ,David M Holtzman ,Tarja Malm ,Rohan T Ranasinghe ,David Klenerman ,Suman De

Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer's pathology and dementia in the CFAS population-derived neuropathology cohort

CFAS 人群神经病理学队列中脑胆固醇和胆固醇生物合成酶与阿尔茨海默病病理和痴呆的关系

Hemant Mistry, Connor D Richardson, Adrian Higginbottom, Bridget Ashford, Saif U Ahamed, Zoe Moore, Fiona E Matthews, Carol Brayne, Julie E Simpson, Stephen B Wharton; Cognitive Function and Ageing Study

Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation

TMEM106B 的缺失会破坏自噬体成熟,从而加剧 C9ALS/FTD DPR 病理

Claudia S Bauer, Christopher P Webster, Allan C Shaw, Jannigje R Kok, Lydia M Castelli, Ya-Hui Lin, Emma F Smith, Francisco Illanes-Álvarez, Adrian Higginbottom, Pamela J Shaw, Mimoun Azzouz, Laura Ferraiuolo, Guillaume M Hautbergue, Andrew J Grierson, Kurt J De Vos

SPG15 protein deficits are at the crossroads between lysosomal abnormalities, altered lipid metabolism and synaptic dysfunction

SPG15 蛋白缺陷是溶酶体异常、脂质代谢改变和突触功能障碍的交汇点

Lara Marrone, Paolo M Marchi, Christopher P Webster, Raffaele Marroccella, Ian Coldicott, Steven Reynolds, João Alves-Cruzeiro, Zih-Liang Yang, Adrian Higginbottom, Mukhran Khundadze, Pamela J Shaw, Christian A Hübner, Matthew R Livesey, Mimoun Azzouz

Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis

利用APEX技术对压力颗粒解体进行时空蛋白质组学分析,揭示SUMO化调控及其与ALS发病机制的关联。

Hagai Marmor-Kollet ,Aviad Siany ,Nancy Kedersha ,Naama Knafo ,Natalia Rivkin ,Yehuda M Danino ,Thomas G Moens ,Tsviya Olender ,Daoud Sheban ,Nir Cohen ,Tali Dadosh ,Yoseph Addadi ,Revital Ravid ,Chen Eitan ,Beata Toth Cohen ,Sarah Hofmann ,Claire L Riggs ,Vivek M Advani ,Adrian Higginbottom ,Johnathan Cooper-Knock ,Jacob H Hanna ,Yifat Merbl ,Ludo Van Den Bosch ,Paul Anderson ,Pavel Ivanov ,Tamar Geiger ,Eran Hornstein

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis

星形胶质细胞腺苷脱氨酶损失增加肌萎缩侧索硬化症中的运动神经元毒性

Scott P Allen, Benjamin Hall, Lydia M Castelli, Laura Francis, Ryan Woof, Alexandros P Siskos, Eirini Kouloura, Elizabeth Gray, Alexander G Thompson, Kevin Talbot, Adrian Higginbottom, Monika Myszczynska, Chloe F Allen, Matthew J Stopford, Jordan Hemingway, Claudia S Bauer, Christopher P Webster, Ku

Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS

将 SOD1 基因沉默转化为临床治疗:一种高效、无脱靶、生物标志物支持的 fALS 策略

Tommaso Iannitti, Joseph M Scarrott, Shibi Likhite, Ian R P Coldicott, Katherine E Lewis, Paul R Heath, Adrian Higginbottom, Monika A Myszczynska, Marta Milo, Guillaume M Hautbergue, Kathrin Meyer, Brian K Kaspar, Laura Ferraiuolo, Pamela J Shaw, Mimoun Azzouz

Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

稳定的转基因 C9orf72 斑马鱼模拟了 ALS/FTD 表型的关键方面并揭示了新的病理特征

Matthew P Shaw, Adrian Higginbottom, Alexander McGown, Lydia M Castelli, Evlyn James, Guillaume M Hautbergue, Pamela J Shaw, Tennore M Ramesh