日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting low levels of MIF expression as a potential therapeutic strategy for ALS

以降低MIF表达水平为靶点,探索治疗ALS的潜在策略。

Leenor Alfahel ,Thomas Gschwendtberger ,Velina Kozareva ,Laura Dumas ,Rachel Gibbs ,Alexander Kertser ,Kuti Baruch ,Shir Zaccai ,Joy Kahn ,Nadine Thau-Habermann ,Reto Eggenschwiler ,Jared Sterneckert ,Andreas Hermann ,Niveda Sundararaman ,Vineet Vaibhav ,Jennifer E Van Eyk ,Victor F Rafuse ,Ernest Fraenkel ,Tobias Cantz ,Susanne Petri ,Adrian Israelson

Protocol for handling and using SOD1 mice for amyotrophic lateral sclerosis pre-clinical studies

处理和使用 SOD1 小鼠进行肌萎缩侧索硬化症临床前研究的方案

Leenor Alfahel, Aleksandar Rajkovic, Adrian Israelson

MIF homolog d-dopachrome tautomerase (D-DT/MIF-2) does not inhibit accumulation and toxicity of misfolded SOD1

MIF 同源物 d-多巴色素互变异构酶 (D-DT/MIF-2) 不抑制错误折叠的 SOD1 的积累和毒性

Amina Alaskarov #, Shir Barel #, Shamchal Bakavayev, Joy Kahn, Adrian Israelson

4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice

4-苯基丁酸 (4-PBA) 衍生物可在体外预防 SOD1 淀粉样蛋白聚集,且对 SOD1-ALS 小鼠的病情进展无影响

Leenor Alfahel, Shirel Argueti-Ostrovsky, Shir Barel, Mahmood Ali Saleh, Joy Kahn, Salome Azoulay-Ginsburg, Ayelet Rothstein, Simon Ebbinghaus, Arie Gruzman, Adrian Israelson

Empty mesoporous silica particles significantly delay disease progression and extend survival in a mouse model of ALS

空介孔二氧化硅颗粒显著延缓了 ALS 小鼠模型的病情进展并延长了生存期

Marcel F Leyton-Jaimes, Patrik Ivert, Jan Hoeber, Yilin Han, Adam Feiler, Chunfang Zhou, Stanislava Pankratova, Varda Shoshan-Barmatz, Adrian Israelson, Elena N Kozlova

Cu/Zn-superoxide dismutase and wild-type like fALS SOD1 mutants produce cytotoxic quantities of H2O2 via cysteine-dependent redox short-circuit

Cu/Zn-超氧化物歧化酶和野生型 fALS SOD1 突变体通过半胱氨酸依赖性氧化还原短路产生细胞毒性量的 H2O2

Shamchal Bakavayev, Nimrod Chetrit, Tatiana Zvagelsky, Rasha Mansour, Maria Vyazmensky, Zeev Barak, Adrian Israelson, Stanislav Engel

MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS

MIF 抑制错误折叠的 SOD1 淀粉样蛋白聚集体的形成和毒性:对家族性 ALS 的影响

Neta Shvil, Victor Banerjee, Guy Zoltsman, Tom Shani, Joy Kahn, Salah Abu-Hamad, Niv Papo, Stanislav Engel, Jurgen Bernhagen, Adrian Israelson

Endogenous macrophage migration inhibitory factor reduces the accumulation and toxicity of misfolded SOD1 in a mouse model of ALS

内源性巨噬细胞移动抑制因子可降低 ALS 小鼠模型中错误折叠的 SOD1 的积累和毒性

Marcel F Leyton-Jaimes, Clara Benaim, Salah Abu-Hamad, Joy Kahn, Amos Guetta, Richard Bucala, Adrian Israelson