日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective inhibition of integrin αvβ6 leads to rapid induction of urinary bladder tumors in cynomolgus macaques

选择性抑制整合素αvβ6可导致食蟹猴膀胱肿瘤快速诱发

Magali Guffroy, Bruce Trela, Takahito Kambara, Lukasz Stawski, Huidong Chen, Lia Luus, Monica S Montesinos, Lauren Olson, Yupeng He, Kevin Maisonave, Tracy Carr, Min Lu, Adrian S Ray, Lisa A Hazelwood

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

冠状病毒对抗病毒药物瑞德西韦 (GS-5734) 的敏感性由病毒聚合酶和校对核酸外切酶介导

Maria L Agostini #, Erica L Andres #, Amy C Sims, Rachel L Graham, Timothy P Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y Feng, Robert Jordan, Adrian S Ray, Tomas Cihlar, Dustin Siegel, Richard L Mackman, Michael O Clarke, Ralph S Baric, Mark R Denison

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

GS-5734 及其母体核苷类似物可抑制丝状病毒、肺炎病毒和副粘液病毒

Michael K Lo, Robert Jordan, Aaron Arvey, Jawahar Sudhamsu, Punya Shrivastava-Ranjan, Anne L Hotard, Mike Flint, Laura K McMullan, Dustin Siegel, Michael O Clarke, Richard L Mackman, Hon C Hui, Michel Perron, Adrian S Ray, Tomas Cihlar, Stuart T Nichol, Christina F Spiropoulou

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

小分子GS-5734对恒河猴埃博拉病毒的治疗效果

Travis K Warren, Robert Jordan, Michael K Lo, Adrian S Ray, Richard L Mackman, Veronica Soloveva, Dustin Siegel, Michel Perron, Roy Bannister, Hon C Hui, Nate Larson, Robert Strickley, Jay Wells, Kelly S Stuthman, Sean A Van Tongeren, Nicole L Garza, Ginger Donnelly, Amy C Shurtleff, Cary J Retterer

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus

线粒体 RNA 聚合酶在丙型肝炎病毒核苷酸抑制剂毒性中的作用

Joy Y Feng, Yili Xu, Ona Barauskas, Jason K Perry, Shekeba Ahmadyar, George Stepan, Helen Yu, Darius Babusis, Yeojin Park, Krista McCutcheon, Michel Perron, Brian E Schultz, Roman Sakowicz, Adrian S Ray

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)

二甲双胍是人类硫胺素转运蛋白 THTR-2 (SLC19A3) 的底物和抑制剂

Xiaomin Liang, Huan-Chieh Chien, Sook Wah Yee, Marilyn M Giacomini, Eugene C Chen, Meiling Piao, Jia Hao, Jolyn Twelves, Eve-Irene Lepist, Adrian S Ray, Kathleen M Giacomini

A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome

替诺福韦相关范康尼综合征的药物遗传学候选基因研究

Amber Dahlin, Matthias Wittwer, Melanie de la Cruz, Jonathan M Woo, Rujuta Bam, Valeska Scharen-Guivel, John Flaherty, Adrian S Ray, Tomas Cihlar, Samir K Gupta, Kathleen M Giacomini

Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620

抗丙型肝炎病毒核苷酸前药 GS-6620 的代谢和药代动力学

Eisuke Murakami, Ting Wang, Darius Babusis, Eve-Irene Lepist, Dorothea Sauer, Yeojin Park, Jennifer E Vela, Robert Shih, Gabriel Birkus, Dimitrios Stefanidis, Choung U Kim, Aesop Cho, Adrian S Ray

Mechanism of active renal tubular efflux of tenofovir

替诺福韦主动肾小管外排机制

Adrian S Ray, Tomas Cihlar, Kelly L Robinson, Leah Tong, Jennifer E Vela, Michael D Fuller, Lani M Wieman, Eugene J Eisenberg, Gerry R Rhodes