日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A conserved core region of the scaffold NEMO is essential for signal-induced conformational change and liquid-liquid phase separation

支架 NEMO 的保守核心区域对于信号诱导的构象变化和液-液相分离至关重要

Christopher J DiRusso, Anthony M DeMaria, Judy Wong, Wei Wang, Jack J Jordanides, Adrian Whitty, Karen N Allen, Thomas D Gilmore

A Conserved Core Region of the Scaffold NEMO is Essential for Signal-induced Conformational Change and Liquid-liquid Phase Separation

支架 NEMO 的保守核心区域对于信号诱导的构象变化和液-液相分离至关重要

Christopher J DiRusso, Anthony M DeMaria, Judy Wong, Jack J Jordanides, Adrian Whitty, Karen N Allen, Thomas D Gilmore

The anti-Müllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor

抗苗勒氏管激素前结构域与激素受体二价结合后,从激素/前结构域复合物中移出

Richard L Cate, Nathalie di Clemente, Chrystèle Racine, Nigel P Groome, R Blake Pepinsky, Adrian Whitty

Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2)

类 ECH 相关蛋白 1 (KEAP1) 与核因子红细胞 2 样 2 (Nrf2) 之间的蛋白质-蛋白质相互作用的相互作用能量学和药物可行性

Mengqi Zhong, Andrew Lynch, Samantha N Muellers, Stefan Jehle, Lingqi Luo, David R Hall, Reina Iwase, James P Carolan, Megan Egbert, Amanda Wakefield, Kristina Streu, Christine M Harvey, Paula C Ortet, Dima Kozakov, Sandor Vajda, Karen N Allen, Adrian Whitty

Quantitative analysis of receptor tyrosine kinase-effector coupling at functionally relevant stimulus levels

功能相关刺激水平上受体酪氨酸激酶效应物偶联的定量分析

Simin Li, Devayani Bhave, Jennifer M Chow, Thomas V Riera, Sandra Schlee, Simone Rauch, Mariya Atanasova, Richard L Cate, Adrian Whitty

Ligand deconstruction: Why some fragment binding positions are conserved and others are not

配体解构:为什么有些片段结合位置被保留,而其他的则不保留

Dima Kozakov, David R Hall, Stefan Jehle, Lingqi Luo, Stefan O Ochiana, Elizabeth V Jones, Michael Pollastri, Karen N Allen, Adrian Whitty, Sandor Vajda

Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity

非必需半胱氨酸突变表明 NF-κB 必需调节剂形成组成性非共价二聚体,以高亲和力结合 IκB 激酶-β

Shaun M Cote, Thomas D Gilmore, Robert Shaffer, Urs Weber, Rishitha Bollam, Mary S Golden, Kimberley Glover, Melanie Herscovitch, Thomas Ennis, Karen N Allen, Adrian Whitty

Determining the affinity and stoichiometry of interactions between unmodified proteins in solution using Biacore

使用 Biacore 确定溶液中未修饰蛋白质之间相互作用的亲和力和化学计量

Eric S Day, Allan D Capili, Christopher W Borysenko, Mohammad Zafari, Adrian Whitty

Binding efficiency of protein-protein complexes

蛋白质-蛋白质复合物的结合效率

Eric S Day, Shaun M Cote, Adrian Whitty

Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism

通过亚基断裂机制对 TNF 家族细胞因子 CD40 配体的小分子抑制

Laura F Silvian, Jessica E Friedman, Kathy Strauch, Teresa G Cachero, Eric S Day, Fang Qian, Brian Cunningham, Amy Fung, Lihong Sun, Gerald W Shipps, Lihe Su, Zhongli Zheng, Gnanasambandam Kumaravel, Adrian Whitty