日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Unveiling the Mechanism of Action of Palmitic Acid, a Human Topoisomerase 1B Inhibitor from the Antarctic Sponge Artemisina plumosa

揭示棕榈酸（一种来自南极海绵 Artemisina plumosa 的人类拓扑异构酶 1B 抑制剂）的作用机制

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms26052018
Ottaviani, Alessio; Pietrafesa, Davide; Soren, Bini Chhetri; Dasari, Jagadish Babu; Olsen, Stine S H; Messina, Beatrice; Demofonti, Francesco; Chicarella, Giulia; Agama, Keli; Pommier, Yves; Morozzo Della Rocca, Blasco; Iacovelli, Federico; Romeo, Alice; Falconi, Mattia; Baker, Bill J; Fiorani, Paola
Human
发表日期：2025
文献求助 收藏

Potent β-lactam-based tyrosyl-DNA phosphodiesterase 1 inhibitors identified by a virtual screen.

通过虚拟筛选鉴定出强效β-内酰胺类酪氨酰-DNA磷酸二酯酶1抑制剂

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-12503-8
Zhao Xue Zhi, Wang Wenjie, Suazo Kiall F, Al Mahmud Md Rasel, Agama Keli, Lountos George T, Andresson Thorkell, Pommier Yves, Burke Terrence R Jr
信号转导
发表日期：2025
文献求助 收藏

From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica

从南极到癌症研究：来自南极海绵树状海绵（Dendrilla antarctica）的新型人类DNA拓扑异构酶1B抑制剂

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2022.2078320
Ottaviani, Alessio; Welsch, Joshua; Agama, Keli; Pommier, Yves; Desideri, Alessandro; Baker, Bill J; Fiorani, Paola
肿瘤
肿瘤免疫
发表日期：2022
文献求助 收藏

2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights

2-芳基喹啉类化合物作为新型抗癌药物，具有双重EGFR/FAK激酶抑制活性：合成、生物学评价和分子建模研究

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2021.2015344
Elbadawi, Mostafa M; Eldehna, Wagdy M; Abd El-Hafeez, Amer Ali; Somaa, Warda R; Albohy, Amgad; Al-Rashood, Sara T; Agama, Keli K; Elkaeed, Eslam B; Ghosh, Pradipta; Pommier, Yves; Abe, Manabu
信号转导
EGFR
FAK
EGF
肿瘤
肿瘤免疫
发表日期：2022
文献求助 收藏

Alkyne Activation in the Diversity Oriented Synthesis of sp(2) -Rich Scaffolds: A Biased Library Approach for Targeting Polynucleotides (DNA/RNA)

炔烃活化在sp(2)富集骨架多样性导向合成中的应用：一种针对多核苷酸（DNA/RNA）的偏向性文库方法

期刊:Chemistry-A European Journal
影响因子:3.7
doi:10.1002/chem.202201925
Chen, Shuqi; Priebbenow, Daniel L; Somkhit, Julie; Scullino, Carmen V; Agama, Keli; Pommier, Yves; Flynn, Bernard L
发表日期：2022
文献求助 收藏

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

合成甲氧基、亚甲二氧基、羟基和卤素取代的苯并菲啶酮衍生物作为DNA拓扑异构酶IB (TOP1) 和酪氨酰-DNA磷酸二酯酶1 (TDP1) 抑制剂及其对耐药性癌症的生物活性

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.1c00318
Hu, De-Xuan; Tang, Wen-Lin; Zhang, Yu; Yang, Hao; Wang, Wenjie; Agama, Keli; Pommier, Yves; An, Lin-Kun
TOP1
肿瘤
肿瘤免疫
发表日期：2021
文献求助 收藏

The synthesis of furoquinolinedione and isoxazoloquinolinedione derivatives as selective Tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors

呋喃喹啉二酮和异噁唑喹啉二酮衍生物作为选择性酪氨酰-DNA磷酸二酯酶2 (TDP2) 抑制剂的合成

期刊:Bioorganic Chemistry
影响因子:4.7
doi:10.1016/j.bioorg.2021.104881
Yang, Hao; Zhu, Xiao-Qing; Wang, Wenjie; Chen, Yu; Hu, Zhu; Zhang, Yu; Hu, De-Xuan; Yu, Le-Mao; Agama, Keli; Pommier, Yves; An, Lin-Kun
发表日期：2021
文献求助 收藏

Design and synthesis of C-aryl angular luotonins via a one-pot aza-Nazarov-Friedlander sequence and their Topo-I inhibition studies along with C-aryl vasicinones and luotonins

通过一锅法氮杂-Nazarov-Friedlander反应设计并合成C-芳基角状luotonins，并研究其拓扑异构酶I抑制活性，同时研究了C-芳基vasicinones和luotonins的活性。

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2021.127998
Rasapalli, Sivappa; Sammeta, Vamshikrishna Reddy; Murphy, Zachary F; Golen, James A; Agama, Keli; Pommier, Yves; Savinov, Sergey N
发表日期：2021
文献求助 收藏

Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells

拓扑异构酶I驱动的NER缺陷细胞中紫外线诱导损伤的修复

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1920165117
Saha, Liton Kumar; Wakasugi, Mitsuo; Akter, Salma; Prasad, Rajendra; Wilson, Samuel H; Shimizu, Naoto; Sasanuma, Hiroyuki; Huang, Shar-Yin Naomi; Agama, Keli; Pommier, Yves; Matsunaga, Tsukasa; Hirota, Kouji; Iwai, Shigenori; Nakazawa, Yuka; Ogi, Tomoo; Takeda, Shunichi
细胞生物学
发表日期：2020
文献求助 收藏

Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2).

人类拓扑异构酶 1、酪氨酰-DNA 磷酸二酯酶 1 (Tdp1) 和酪氨酰-DNA 磷酸二酯酶 2 (Tdp2) 的首个三重抑制剂的合成和生物学评价

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.6b01565
Wang Ping, Elsayed Mohamed S A, Plescia Caroline B, Ravji Azhar, Redon Christophe E, Kiselev Evgeny, Marchand Christophe, Zeleznik Olga, Agama Keli, Pommier Yves, Cushman Mark
其它
Human
发表日期：2017
文献求助 收藏