日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Design of high-affinity binders to immune modulating receptors for cancer immunotherapy

设计与免疫调节受体具有高亲和力的结合剂用于癌症免疫治疗

Wei Yang ,Derrick R Hicks ,Agnidipta Ghosh ,Tristin A Schwartze ,Brian Conventry ,Inna Goreshnik ,Aza Allen ,Samer F Halabiya ,Chan Johng Kim ,Cynthia S Hinck ,David S Lee ,Asim K Bera ,Zhe Li ,Yujia Wang ,Thomas Schlichthaerle ,Longxing Cao ,Buwei Huang ,Sarah Garrett ,Stacey R Gerben ,Stephen Rettie ,Piper Heine ,Analisa Murray ,Natasha Edman ,Lauren Carter ,Lance Stewart ,Steven C Almo ,Andrew P Hinck ,David Baker

Structural basis for sensitivity and acquired resistance of fungal cap guanine-N7 methyltransferases to the antifungal antibiotic sinefungin

真菌帽鸟嘌呤-N7甲基转移酶对抗菌抗生素西尼芬净的敏感性和获得性耐药性的结构基础

Nilson, Daniel J; Schwer, Beate; Almo, Steven C; Shuman, Stewart; Ghosh, Agnidipta

A hemoprotein with a zinc-mirror heme site ties heme availability to carbon metabolism in cyanobacteria

蓝藻中一种具有锌镜像血红素位点的血红素蛋白将血红素的可用性与碳代谢联系起来。

Nicolas Grosjean,Estella F Yee,Desigan Kumaran,Kriti Chopra,Macon Abernathy,Sandeep Biswas,James Byrnes,Dale F Kreitler,Jan-Fang Cheng,Agnidipta Ghosh,Steven C Almo,Masakazu Iwai,Krishna K Niyogi,Himadri B Pakrasi,Ritimukta Sarangi,Hubertus van Dam,Lin Yang,Ian K Blaby,Crysten E Blaby-Haas

Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes

与 1 型糖尿病差异相关的高度相似 HLA-B 同种型的结构和生化分析

Ruby Sharma, Nitin P Amdare, Agnidipta Ghosh, Jennifer Schloss, John Sidney, Scott J Garforth, Yessenia Lopez, Alev Celikgil, Alessandro Sette, Steven C Almo, Teresa P DiLorenzo

Insights into the Interaction Landscape of the EVH1 Domain of Mena

对 Mena EVH1 结构域相互作用格局的深入研究

LaComb, Lanette; Ghosh, Agnidipta; Bonanno, Jeffrey B; Nilson, Daniel J; Poppel, Alex J; Dada, Lucas; Cahill, Sean M; Maianti, Juan Pablo; Kitamura, Seiya; Cowburn, David; Almo, Steven C

Identification of coumarin derivatives targeting acetylcholinesterase for Alzheimer's disease by field-based 3D-QSAR, pharmacophore model-based virtual screening, molecular docking, MM/GBSA, ADME and MD Simulation study

通过基于场的三维定量构效关系(3D-QSAR)、基于药效团模型的虚拟筛选、分子对接、分子力学/几何构效关系(MM/GBSA)、吸收、分布、代谢和排泄(ADME)以及分子动力学模拟研究,鉴定靶向乙酰胆碱酯酶的香豆素衍生物用于治疗阿尔茨海默病。

Saha, Bikram; Das, Agnidipta; Jangid, Kailash; Kumar, Amit; Kumar, Vinod; Jaitak, Vikas

Design of High Affinity Binders to Convex Protein Target Sites

凸蛋白靶位高亲和力结合物的设计

Wei Yang, Derrick R Hicks, Agnidipta Ghosh, Tristin A Schwartze, Brian Conventry, Inna Goreshnik, Aza Allen, Samer F Halabiya, Chan Johng Kim, Cynthia S Hinck, David S Lee, Asim K Bera, Zhe Li, Yujia Wang, Thomas Schlichthaerle, Longxing Cao, Buwei Huang, Sarah Garrett, Stacey R Gerben, Stephen Rett

Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection

原钙粘蛋白-1 中的两个点突变破坏了汉坦病毒识别并提供了对致命感染的保护

Megan M Slough #, Rong Li #, Andrew S Herbert #, Gorka Lasso, Ana I Kuehne, Stephanie R Monticelli, Russell R Bakken, Yanan Liu, Agnidipta Ghosh, Alicia M Moreau, Xiankun Zeng, Félix A Rey, Pablo Guardado-Calvo, Steven C Almo, John M Dye, Rohit K Jangra, Zhongde Wang, Kartik Chandran

Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase

恶性疟原虫次黄嘌呤-鸟嘌呤-黄嘌呤磷酸核糖转移酶的抑制及其机制

V T Minnow, Yacoba; Suthagar, Kajitha; Clinch, Keith; Ducati, Rodrigo G; Ghosh, Agnidipta; Buckler, Joshua N; Harijan, Rajesh K; Cahill, Sean M; Tyler, Peter C; Schramm, Vern L

Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A.

人类蛋氨酸腺苷转移酶2A的机制和抑制

Niland Courtney N, Ghosh Agnidipta, Cahill Sean M, Schramm Vern L