日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial

SHR-A1811,一种新型靶向 HER2 的抗体药物偶联物,在晚期实体瘤中的应用(HORIZON-X):一项全球 1 期试验

Yao, Herui; Yan, Min; Tong, Zhongsheng; Wu, Xinhong; Yin, Yongmei; Ryu, Min-Hee; Park, John J; Jiang, Shusuan; Kim, Jee Hyun; Wang, Shouman; Zhong, Yahua; Voskoboynik, Mark; Zhang, Jian; Kaubisch, Andreas; Liu, Caigang; Chen, Yu; Im, Seock-Ah; Wu, Lingying; Liu, Yingbin; Ganju, Vinod; Barve, Minal; Li, Hui; Yao, Guangyu; Yang, Mudan; Bao, Lequn; Zhao, Yiming; Zhao, Jianli; Zhao, Kaijing; Shen, Yu; Rong, Shangyi; Zhu, Xiaoyu; Song, Erwei

Homologous recombination deficiency and hemizygosity drive resistance in breast cancer

同源重组缺陷和半合子状态是乳腺癌耐药性的驱动因素

Safonov, Anton; Lee, Minna; Brown, David N; Boscolo Bielo, Luca; Mehine, Miika; Bandlamudi, Chaitanya; O'Leary, Ben; Shao, Hong; Vicente, Laia; Muldoon, Daniel; Zhu, Allen; Ros, Susana; Marra, Antonio; Selenica, Pier; Bieche, Ivan; Wubbenhorst, Bradley; Ferraro, Emanuela; Courtois, Laura; El Botty, Rania; Ahmed, Mehnaj; Moiso, Enrico; An, Julia Ah-Reum; Donoghue, Mark T A; Will, Marie; Pareja, Fresia; Nizialek, Emily; Lukashchuk, Natalia; Sofianopoulou, Eleni; Liu, Yuan; Huang, Xin; Chappey, Colombe; Staniszewska, Anna D; Ross, Dara; Mandelker, Diana; Ladanyi, Marc; Schultz, Nikolaus; Berger, Michael F; Scaltriti, Maurizio; Reis-Filho, Jorge S; Li, Bob T; Offit, Kenneth; Norton, Larry; Shen, Ronglai; Maxwell, Kara N; Couch, Fergus; Domchek, Susan M; Marangoni, Elisabetta; Shah, Sohrab; Albertella, Mark R; Serra, Violeta; Weigelt, Britta; Solit, David B; Nathanson, Katherine L; Robson, Mark E; Turner, Nicholas C; Chandarlapaty, Sarat; Razavi, Pedram

Clonal Hematopoiesis and Risk of Trastuzumab-Related Cardiotoxic Effects

克隆性造血与曲妥珠单抗相关心脏毒性风险

Park, Chan Soon; Ryu, Gangpyo; Ahn, Hyo-Jeong; Sun, Choonghyun; Lee, Seung-Pyo; Kim, Hyung-Kwan; Kim, Yong-Jin; Jeon, Sook Young; Lee, Han-Byoel; Moon, Hyeong-Gon; Han, Wonshik; Lee, Dae-Won; Lee, Kyung-Hun; Han, Sae-Won; Im, Seock-Ah; Lee, Sang Eun; Jaiswal, Siddhartha; Koh, Youngil; Park, Jun-Bean

Zanidatamab in HER2-Positive Metastatic Biliary Tract Cancer: Final Results From HERIZON-BTC-01

Zanidatamab治疗HER2阳性转移性胆道癌:HERIZON-BTC-01研究的最终结果

Pant, Shubham; Fan, Jia; Oh, Do-Youn; Choi, Hye Jin; Kim, Jin Won; Chang, Heung-Moon; Bao, Lequn; Sun, Hui-Chuan; Macarulla, Teresa; Xie, Feng; Metges, Jean-Phillippe; Ying, Jie'er; Bridgewater, John; Lee, Myung-Ah; Tejani, Mohamedtaki A; Chen, Emerson Y; Wasan, Harpreet; Ducreux, Michel; Bao, Yuanyuan; Wu, Xiaotian; Zhao, Yi; Garfin, Phillip M; Gable, Jonathon; Harding, James J

Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels

通过构建果蝇组织特异性代谢模型,揭示了高糖饮食诱导的肌肉代谢紊乱,这种紊乱发生在反应和通路层面。

Moon, Sun Jin; Hu, Yanhui; Dzieciatkowska, Monika; Kim, Ah-Ram; Asara, John M; D'Alessandro, Angelo; Perrimon, Norbert

Origins of the Intrinsic Redox Activity of Biomolecular Condensates

生物分子凝聚体固有氧化还原活性的起源

Yu, Wen; Zhou, Yanrun; Yang, Leshan; Yan, Xiao; Smukowski, Samuel N; Ma, Yuefeng; Fan, Jiali; Goo, Young Ah; Hyman, Anthony A; Dai, Yifan

Cancer Manipulates Adjacent Adipose Tissue to Exploit Fatty Acids via HIF-1α/CCL2/PPARα Axis: A Metabolic Circuit to Support Tumor Progression.

癌细胞通过 HIF-1α/CCL2/PPARα 轴操纵邻近脂肪组织以利用脂肪酸:一种支持肿瘤进展的代谢回路。

Yun Jeong-Eun, Seo Jieun, Koh Jiwon, Im Seock-Ah, Hong Ki Yong, Son Yeseon, Jeong Do-Won, Fukuda Junji, Park Jong-Wan, Chun Yang-Sook

Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1-Mediated Mechanotransduction.

工程水凝胶提供的机械环境通过 Piezo1 介导的机械转导,对移植到受损脊髓中的神经干细胞的存活起着至关重要的调节作用。

Park Hee Hwan, Kim Yurim, Jang Byeong Seong, Genişcan Simay, Hwang Dong Hoon, Seo Yeojin, Jee Seung-Ah, Seo Hyo Gyeong, Kim Hyung Soon, Einisadr Ariandokht, Kim Ho-Jeong, Lee Seolhee, Kwon Sangwoo, Kim Kyung Sook, Lee Kang In, Lee Jae Young, Park Joo Min, Kim Young-Min, Song Soo-Chang, Kim Byung Gon

Diabetes exacerbates destructive inflammation by activating the CD137L-CD137 axis in dendritic and IL-17+ T cells

糖尿病通过激活树突状细胞和IL-17+ T细胞中的CD137L-CD137轴加剧破坏性炎症。

Huang, Xin; Liu, Min; Gonzalez, Michael V; Debnath, Rahul; Afzali, Hamideh; Choi, Yongwon; Kim, Su Ah; Ko, Kang I; Graves, Dana T

B-type lamins maintain transcriptional homeostasis by spatially controlling chromatin-speckle proximity.

B型核纤层蛋白通过空间控制染色质斑点的接近程度来维持转录稳态。

Shin Geun-Seup, Kim Jinho, Kim Ji-Young, Kim Chul-Hong, An Mi-Jin, Lee Hyun-Min, Jo Ah-Ra, Park Yuna, Hwangbo Yujeong, Hong Tae Kyung, Jung Youn-Sang, Rhee Sangmyung, Kim Jung-Woong