日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RAS-GTP Inhibition Overcomes Acquired Resistance to KRASG12C Inhibitors Mediated by Oncogenic and Wild-Type RAS Activation in Non-Small Cell Lung Cancer

RAS-GTP抑制剂可克服非小细胞肺癌中由致癌性和野生型RAS激活介导的对KRASG12C抑制剂的获得性耐药性

Solanki, Hitendra S; Shah, Harshit; Imbody, Denis; Desai, Bina; Kato, Ryoji; Miroshnychenko, Daria; Stern, Yaakov E; Majumder, Anurima; Sarcar, Bhaswati; Xieraili, Aobuli; Stewart, Paul A; Fang, Bin; Zhang, Yonghong; Yao, Jiqiang; Darville, Lancia N; Koomen, John M; Rix, Uwe; Evans, James W; Yang, Yu Chi; Ahler, Ethan; Marusyk, Andriy; Singh, Mallika; Aronchik, Ida; Haura, Eric B

Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics.

大规模分析 Src 激酶的耐药性,揭示了一个将自身抑制和催化结构域动力学耦合起来的调控网络

Chakraborty Sujata, Ahler Ethan, Simon Jessica J, Fang Linglan, Potter Zachary E, Sitko Katherine A, Stephany Jason J, Guttman Miklos, Fowler Douglas M, Maly Dustin J

Molecular determinants of Hsp90 dependence of Src kinase revealed by deep mutational scanning

通过深度突变扫描揭示了Src激酶对Hsp90依赖性的分子决定因素

Nguyen, Vanessa; Ahler, Ethan; Sitko, Katherine A; Stephany, Jason J; Maly, Dustin J; Fowler, Douglas M

Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment

代谢组学策略揭示了对吉西他滨治疗敏感的脂肪肉瘤亚群

Braas, Daniel; Ahler, Ethan; Tam, Brenna; Nathanson, David; Riedinger, Mirielle; Benz, Matthias R; Smith, Kathleen B; Eilber, Fritz C; Witte, Owen N; Tap, William D; Wu, Hong; Christofk, Heather R