日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11-Mutant Tumors to Anti-PD-1 Immunotherapy.

TNG260 是一种小分子 CoREST 抑制剂,可使 STK11 突变肿瘤对 PD-1 抗肿瘤免疫疗法敏感。

Ahronian Leanne G, Sahu Soumyadip, Zhang Minjie, Patel Ayushi S, Geng Ke, Bhattacharya Reshmee, Falchook Gerald S, Goldman Jonathan W, Spira Alexander I, Punekar Salman R, Spigel David R, Wang Judy S, Skoulidis Ferdinandos, Stephens Janaye, Meynardie Mary, Powell Jaylen M, Lopez Alfonso, Ranieri Michela, Ploszaj Magdalena A, Tan Yi Jer, Lee Yeuan Ting, Yu Yi, Deng Jiehui, Chen Ting, McCarren Patrick, Tsai Alice, Hussain Suleman S, Doyon Brian, Amemiya Kenjie, Ermolieff Jacques, Shahagadkar Preksha, Das Nikitha M, Flynn Lauren R, Shields Julie A, Danielczyk Laney, McMillan Brian J, Mignault Andre, Meier Samuel R, Wu Hsin-Jung, Guerin David J, Whittington Douglas A, Min Chengyin, Sienczylo Iga, Maxwell John P, DiBenedetto Heather J, Watanabe Hideo, Haines Brian B, Huang Alan, Crystal Adam, Andersen Jannik N, Wu Xinyuan, Wong Kwok-Kin

LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers.

LIG1 是 BRCA1 突变癌症中的合成致死靶点

Martires Lauren Catherine M, Ahronian Leanne G, Pratt Charlotte B, Das Nikitha M, Zhang Xiaobin, Whittington Douglas A, Zhang Hongxiang, Shen Binzhang, Come Jon, McCarren Patrick, Liu Mu-Sen, Min Chengyin, Feng Tianshu, Jahic Haris, Ali Janid A, Aird Daniel R, Li Fang, Andersen Jannik N, Huang Alan, Mallender William D, Nicholson Hilary E

Comprehensively Testing the Function of Missense Variation in the STK11 Tumour Suppressor

全面检验STK11肿瘤抑制基因错义变异的功能

Zimmerman, Daniel; Cote, Atina; van Loggerenberg, Warren; Gebbia, Marinella; Kishore, Nishka; Weile, Jochen; Li, Roujia; Reno, Chloe; Marsh, Ashley Pl; Hernandez, Felicia; Shahagadkar, Preksha; Grove, Lauren; Meier, Samuel R; Wu, Hsin-Jung; Fenoglio, Silvia; Ahronian, Leanne; Teng, Teng; Waters, Andrew J; Seward, David; Taipale, Mikko; Aronson, Melyssa; Richardson, Marcy E; Adams, David J; Roth, Frederick P

Phase I/II Study of Combined BCL-xL and MEK Inhibition with Navitoclax and Trametinib in KRAS or NRAS Mutant Advanced Solid Tumors

纳维托克和曲美替尼联合抑制BCL-xL和MEK治疗KRAS或NRAS突变晚期实体瘤的I/II期研究

Corcoran, Ryan B; Do, Khanh T; Kim, Jeong E; Cleary, James M; Parikh, Aparna R; Yeku, Oladapo O; Xiong, Niya; Weekes, Colin D; Veneris, Jennifer; Ahronian, Leanne G; Mauri, Gianluca; Tian, Jun; Norden, Bryanna L; Michel, Alexa G; Van Seventer, Emily E; Siravegna, Giulia; Camphausen, Kyle; Chi, Gary; Fetter, Isobel J; Brugge, Joan S; Chen, Helen; Takebe, Naoko; Penson, Richard T; Juric, Dejan; Flaherty, Keith T; Sullivan, Ryan J; Clark, Jeffrey W; Heist, Rebecca S; Matulonis, Ursula A; Liu, Joyce F; Shapiro, Geoffrey I

Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer

结直肠癌患者游离DNA的基因组图谱

Strickler, John H; Loree, Jonathan M; Ahronian, Leanne G; Parikh, Aparna R; Niedzwiecki, Donna; Pereira, Allan Andresson Lima; McKinney, Matthew; Korn, W Michael; Atreya, Chloe E; Banks, Kimberly C; Nagy, Rebecca J; Meric-Bernstam, Funda; Lanman, Richard B; Talasaz, AmirAli; Tsigelny, Igor F; Corcoran, Ryan B; Kopetz, Scott

Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in BRAFV600E Colorectal Cancer

融合治疗策略以克服 BRAFV600E 结直肠癌获得性耐药的异质性

Mehlika Hazar-Rethinam, Marianna Kleyman, G Celine Han, David Liu, Leanne G Ahronian, Heather A Shahzade, Lifeng Chen, Aparna R Parikh, Jill N Allen, Jeffrey W Clark, Eunice L Kwak, Jason E Faris, Janet E Murphy, Theodore S Hong, Emily E Van Seventer, Brandon Nadres, Catriona B Hong, Joseph M Gurski

Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma

多克隆继发性 FGFR2 突变导致 FGFR2 融合阳性胆管癌患者对 FGFR 抑制产生获得性耐药

Lipika Goyal, Supriya K Saha, Leah Y Liu, Giulia Siravegna, Ignaty Leshchiner, Leanne G Ahronian, Jochen K Lennerz, Phuong Vu, Vikram Deshpande, Avinash Kambadakone, Benedetta Mussolin, Stephanie Reyes, Laura Henderson, Jiaoyuan Elisabeth Sun, Emily E Van Seventer, Joseph M Gurski Jr, Sabrina Baltsc

Strategies for monitoring and combating resistance to combination kinase inhibitors for cancer therapy

监测和对抗癌症治疗中联合激酶抑制剂耐药性的策略

Ahronian, Leanne G; Corcoran, Ryan B

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer

结直肠癌的肿瘤异质性和病变特异性靶向治疗反应

Mariangela Russo #, Giulia Siravegna #, Lawrence S Blaszkowsky #, Giorgio Corti, Giovanni Crisafulli, Leanne G Ahronian, Benedetta Mussolin, Eunice L Kwak, Michela Buscarino, Luca Lazzari, Emanuele Valtorta, Mauro Truini, Nicholas A Jessop, Hayley E Robinson, Theodore S Hong, Mari Mino-Kenudson, Fed

Effective MAPK Inhibition is critical for therapeutic responses in colorectal cancer with BRAF mutations

有效抑制MAPK对于BRAF突变型结直肠癌的治疗反应至关重要。

Ahronian, Leanne G; Corcoran, Ryan B