日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2

阿尔茨海默病相关免疫受体 TREM2 的 R47H 变体的功能丧失效应的分子基础

Athena Sudom, Santosh Talreja, Jean Danao, Eric Bragg, Rob Kegel, Xiaoshan Min, Jason Richardson, Zhongqi Zhang, Nikolai Sharkov, Edoardo Marcora, Steve Thibault, Jodi Bradley, Steve Wood, Ai-Ching Lim, Hang Chen, Songli Wang, Ian N Foltz, Shilpa Sambashivan, Zhulun Wang

Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution

膜胆固醇在动态细胞内运输过程中调节 STEAP2 构象,从而导致广泛的亚细胞分布

Haruki Hasegawa, Cong Li, Benjamin M Alba, David M Penny, Zhen Xia, Maria Rosalyn Dayao, Peng Li, Jue Zhang, Jing Zhou, Desiree Lim, Christopher M Murawsky, Ai Ching Lim

A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma

罕见的 IL33 功能丧失突变可降低血液嗜酸性粒细胞计数并预防哮喘

Dirk Smith, Hannes Helgason, Patrick Sulem, Unnur Steina Bjornsdottir, Ai Ching Lim, Gardar Sveinbjornsson, Haruki Hasegawa, Michael Brown, Randal R Ketchem, Monica Gavala, Logan Garrett, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Asgeir Sigurdsson, Olafur T Magnusson, Gudmundur I Eyjolfsson, Isleif

Topogenesis and cell surface trafficking of GPR34 are facilitated by positive-inside rule that effects through a tri-basic motif in the first intracellular loop

GPR34 的拓扑生成和细胞表面运输由正向内部规则促进,该规则通过第一个细胞内环中的三基序发挥作用

Haruki Hasegawa, Neha Patel, Elham Ettehadieh, Peng Li, Ai Ching Lim

Anti-tumor effect of CT-322 as an adnectin inhibitor of vascular endothelial growth factor receptor-2

CT-322 作为血管内皮生长因子受体 2 的 adnectin 抑制剂的抗肿瘤作用

Roni Mamluk, Irvith M Carvajal, Brent A Morse, Henry Wong, Janette Abramowitz, Sharon Aslanian, Ai-Ching Lim, Jochem Gokemeijer, Michael J Storek, Joonsoo Lee, Michael Gosselin, Martin C Wright, Ray T Camphausen, Jack Wang, Yan Chen, Kathy Miller, Kerry Sanders, Sarah Short, Jeff Sperinde, Gargi Pra