Inhibition of mTORC1 by rapamycin results in feedback activation of Akt(S473) and aggravates hallmarks of osteoarthritis in female mice and non-human primates.
雷帕霉素抑制 mTORC1 会导致 Akt(S473) 的反馈激活,并加剧雌性小鼠和非人灵长类动物的骨关节炎特征
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doi:10.1101/2024.05.14.594256
Minton Dennis M, Ailiani Aditya R, Focht Michael D K, Kersh Mariana E, Li Amy, Elliehausen Christian J, Sonsalla Michelle M, Lamming Dudley W, Marolf Angela J, Santangelo Kelly S, Salmon Adam B, Konopka Adam R