日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single-cell transcriptomic and genomic changes in the ageing human brain

衰老人脑中单细胞转录组和基因组的变化

Jeffries, Ailsa M; Yu, Tianxiong; Ziegenfuss, Jennifer S; Tolles, Allie K; Baer, Christina E; Sotelo, Cesar Bautista; Kim, Yerin; Weng, Zhiping; Lodato, Michael A

A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes

一种复发的从头 MAX p.Arg60Gln 变异通过 c-Myc 靶基因的差异表达导致综合征性过度生长障碍。

Harris, Erica L; Roy, Vincent; Montagne, Martin; Rose, Ailsa M S; Livesey, Helen; Reijnders, Margot R F; Hobson, Emma; Sansbury, Francis H; Willemsen, Marjolein H; Pfundt, Rolph; Warren, Daniel; Long, Vernon; Carr, Ian M; Brunner, Han G; Sheridan, Eamonn G; Firth, Helen V; Lavigne, Pierre; Poulter, James A

ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia

ATM 缺陷引起的小胶质细胞活化促进共济失调毛细血管扩张症中的神经退行性

Jenny Lai, Didem Demirbas, Junho Kim, Ailsa M Jeffries, Allie Tolles, Junseok Park, Thomas W Chittenden, Patrick G Buckley, Timothy W Yu, Michael A Lodato, Eunjung Alice Lee

De novo missense variants in RRAGC lead to a fatal mTORopathy of early childhood

RRAGC 中的新生错义变异导致儿童早期发生致命的 mTOR 病

Margot R F Reijnders, Annette Seibt, Melanie Brugger, Ideke J C Lamers, Torsten Ott, Oliver Klaas, Judit Horváth, Ailsa M S Rose, Isabel M Craghill, Theresa Brunet, Elisabeth Graf, Katharina Mayerhanser, Debby Hellebrekers, David Pauck, Eva Neuen-Jacob, Richard J T Rodenburg, Dagmar Wieczorek, Dirk

Single-cell transcriptomic and genomic changes in the aging human brain

人类大脑衰老过程中的单细胞转录组和基因组变化

Ailsa M Jeffries, Tianxiong Yu, Jennifer S Ziegenfuss, Allie K Tolles, Yerin Kim, Zhiping Weng, Michael A Lodato

Prevalence and mechanisms of somatic deletions in single human neurons during normal aging and in DNA repair disorders

正常衰老和DNA修复障碍中单个人类神经元体细胞缺失的发生率和机制

Kim, Junho; Huang, August Yue; Johnson, Shelby L; Lai, Jenny; Isacco, Laura; Jeffries, Ailsa M; Miller, Michael B; Lodato, Michael A; Walsh, Christopher A; Lee, Eunjung Alice

Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction.

ATM激酶缺乏引起的持续性DNA损伤会促进小胶质细胞功能障碍

Bourseguin Julie, Cheng Wen, Talbot Emily, Hardy Liana, Lai Jenny, Jeffries Ailsa M, Lodato Michael A, Lee Eunjung Alice, Khoronenkova Svetlana V

Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition

利用组蛋白去乙酰化酶抑制增强溶瘤病毒诱导的免疫介导的肿瘤细胞杀伤作用

Victoria A Jennings, Gina B Scott, Ailsa M S Rose, Karen J Scott, Gemma Migneco, Brian Keller, Katrina Reilly, Oliver Donnelly, Howard Peach, Donald Dewar, Kevin J Harrington, Hardev Pandha, Adel Samson, Richard G Vile, Alan A Melcher, Fiona Errington-Mais