日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A general assay platform to study protein pharmacology using ligand-dependent structural dynamics.

利用配体依赖性结构动力学研究蛋白质药理学的通用检测平台

Ciulla Daniel A, Dranchak Patricia K, Aitha Mahesh, van Neer Renier H P, Shah Divia, Tharakan Ravi, Wilson Kelli M, Wang Yuhong, Braisted John C, Inglese James

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

单核和双核金属β-内酰胺酶水解碳青霉烯类抗生素的一般反应机理

Lisa, María-Natalia; Palacios, Antonela R; Aitha, Mahesh; González, Mariano M; Moreno, Diego M; Crowder, Michael W; Bonomo, Robert A; Spencer, James; Tierney, David L; Llarrull, Leticia I; Vila, Alejandro J

Probing substrate binding to the metal binding sites in metallo-β-lactamase L1 during catalysis

探究金属β-内酰胺酶L1在催化过程中底物与金属结合位点的结合情况

Aitha, Mahesh; Al-Adbul-Wahid, Sameer; Tierney, David L; Crowder, Michael W

Meropenem and chromacef intermediates observed in IMP-25 metallo-β-lactamase-catalyzed hydrolysis

在IMP-25金属β-内酰胺酶催化的水解过程中观察到美罗培南和色甘酸钠的中间体

Oelschlaeger, Peter; Aitha, Mahesh; Yang, Hao; Kang, Joon S; Zhang, Antonia L; Liu, Eleanor M; Buynak, John D; Crowder, Michael W

Conformational dynamics of metallo-β-lactamase CcrA during catalysis investigated by using DEER spectroscopy

利用双电子自旋共振光谱法研究金属β-内酰胺酶CcrA在催化过程中的构象动力学

Aitha, Mahesh; Moritz, Lindsay; Sahu, Indra D; Sanyurah, Omar; Roche, Zahilyn; McCarrick, Robert; Lorigan, Gary A; Bennett, Brian; Crowder, Michael W

Biochemical, mechanistic, and spectroscopic characterization of metallo-β-lactamase VIM-2

金属β-内酰胺酶VIM-2的生化、机制和光谱学表征

Aitha, Mahesh; Marts, Amy R; Bergstrom, Alex; Møller, Abraham Jon; Moritz, Lindsay; Turner, Lucien; Nix, Jay C; Bonomo, Robert A; Page, Richard C; Tierney, David L; Crowder, Michael W

New β-phospholactam as a carbapenem transition state analog: Synthesis of a broad-spectrum inhibitor of metallo-β-lactamases

新型β-磷内酰胺类化合物作为碳青霉烯类过渡态类似物:金属β-内酰胺酶广谱抑制剂的合成

Yang, Ke-Wu; Feng, Lei; Yang, Shao-Kang; Aitha, Mahesh; LaCuran, Alecander E; Oelschlaeger, Peter; Crowder, Michael W