日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A pooled Cell Painting CRISPR screening platform enables de novo inference of gene function by self-supervised deep learning.

一个汇集细胞涂染 CRISPR 筛选平台能够通过自监督深度学习从头推断基因功能。

Sivanandan Srinivasan, Leitmann Bobby, Lubeck Eric, Sultan Mohammad Muneeb, Stanitsas Panagiotis, Ranu Navpreet, Ewer Alexis, Mancuso Jordan E, Phillips Zachary F, Kim Albert, Bisognano John W, Cesarek John, Ruggiu Fiorella, Feldman David, Koller Daphne, Sharon Eilon, Kaykas Ajamete, Salick Max R, Chu Ci

Biallelic loss-of-function variants in CACHD1 cause a novel neurodevelopmental syndrome with facial dysmorphism and multisystem congenital abnormalities

CACHD1基因的双等位基因功能缺失变异会导致一种新型神经发育综合征,伴有面部畸形和多系统先天性异常。

Scala, Marcello; Khan, Kamal; Beneteau, Claire; Fox, Rachel G; von Hardenberg, Sandra; Khan, Ayaz; Joubert, Madeleine; Fievet, Lorraine; Musquer, Marie; Le Vaillant, Claudine; Holsclaw, Julie Korda; Lim, Derek; Berking, Ann-Cathrine; Accogli, Andrea; Giacomini, Thea; Nobili, Lino; Striano, Pasquale; Zara, Federico; Torella, Annalaura; Nigro, Vincenzo; Cogné, Benjamin; Salick, Max R; Kaykas, Ajamete; Eggan, Kevin; Capra, Valeria; Bézieau, Stéphane; Davis, Erica E; Wells, Michael F

Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages

神经祖细胞群揭示基因表达和病毒易感性的自然变异

Michael F Wells ,James Nemesh ,Sulagna Ghosh ,Jana M Mitchell ,Max R Salick ,Curtis J Mello ,Daniel Meyer ,Olli Pietilainen ,Federica Piccioni ,Ellen J Guss ,Kavya Raghunathan ,Matthew Tegtmeyer ,Derek Hawes ,Anna Neumann ,Kathleen A Worringer ,Daniel Ho ,Sravya Kommineni ,Karrie Chan ,Brant K Peterson ,Joseph J Raymond ,John T Gold ,Marco T Siekmann ,Emanuela Zuccaro ,Ralda Nehme ,Ajamete Kaykas ,Kevin Eggan ,Steven A McCarroll

Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids

N-聚糖酶 1 的缺乏会干扰人类类器官模拟的神经发生和大脑发育

Victor J T Lin #, Jiangnan Hu #, Ashwini Zolekar, Max R Salick, Parul Mittal, Jordan T Bird, Peter Hoffmann, Ajamete Kaykas, Stephanie D Byrum, Yu-Chieh Wang

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

精神分裂症患者来源的突触修剪模型中,小胶质细胞介导的突触消除增加

Carl M Sellgren ,Jessica Gracias ,Bradley Watmuff ,Jonathan D Biag ,Jessica M Thanos ,Paul B Whittredge ,Ting Fu ,Kathleen Worringer ,Hannah E Brown ,Jennifer Wang ,Ajamete Kaykas ,Rakesh Karmacharya ,Carleton P Goold ,Steven D Sheridan ,Roy H Perlis

CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data

CellSIUS能够从复杂的单细胞RNA测序数据中灵敏且特异地检测稀有细胞群。

Rebekka Wegmann ,Marilisa Neri ,Sven Schuierer ,Bilada Bilican ,Huyen Hartkopf ,Florian Nigsch ,Felipa Mapa ,Annick Waldt ,Rachel Cuttat ,Max R Salick ,Joe Raymond ,Ajamete Kaykas ,Guglielmo Roma ,Caroline Gubser Keller

DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery

DRUG-seq 用于药物发现中的微型化高通量转录组分析

Ye, Chaoyang; Ho, Daniel J; Neri, Marilisa; Yang, Chian; Kulkarni, Tripti; Randhawa, Ranjit; Henault, Martin; Mostacci, Nadezda; Farmer, Pierre; Renner, Steffen; Ihry, Robert; Mansur, Leandra; Keller, Caroline Gubser; McAllister, Gregory; Hild, Marc; Jenkins, Jeremy; Kaykas, Ajamete

Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids

利用干细胞衍生的脑类器官在体外模拟寨卡病毒感染发育中的人脑

Salick, Max R; Wells, Michael F; Eggan, Kevin; Kaykas, Ajamete

A viral strategy for targeting and manipulating interneurons across vertebrate species

一种针对和操纵脊椎动物物种中间神经元的病毒策略

Jordane Dimidschstein, Qian Chen, Robin Tremblay, Stephanie L Rogers, Giuseppe-Antonio Saldi, Lihua Guo, Qing Xu, Runpeng Liu, Congyi Lu, Jianhua Chu, Joshua S Grimley, Anne-Rachel Krostag, Ajamete Kaykas, Michael C Avery, Mohammad S Rashid, Myungin Baek, Amanda L Jacob, Gordon B Smith, Daniel E Wil

Genome engineering of isogenic human ES cells to model autism disorders

利用同基因人类胚胎干细胞进行基因组工程来模拟自闭症

Refugio A Martinez, Jason L Stein, Anne-Rachel F Krostag, Angelique M Nelson, John S Marken, Vilas Menon, Ryan C May, Zizhen Yao, Ajamete Kaykas, Daniel H Geschwind, Joshua S Grimley