Deep mutational scanning of CYP2C19 in human cells reveals a substrate specificity-abundance tradeoff.
对人类细胞中 CYP2C19 的深度突变扫描揭示了底物特异性与丰度之间的权衡关系
期刊:Genetics
影响因子:5.1
doi:10.1093/genetics/iyae156
Boyle Gabriel E, Sitko Katherine A, Galloway Jared G, Haddox Hugh K, Bianchi Aisha Haley, Dixon Ajeya, Wheelock Melinda K, Vandi Allyssa J, Wang Ziyu R, Thomson Raine E S, Garge Riddhiman K, Rettie Allan E, Rubin Alan F, Geck Renee C, Gillam Elizabeth M J, DeWitt William S, Matsen Frederick A 4th, Fowler Douglas M